Bladder Flashcards

1
Q

what is urinary incontinence

A

involuntary leakage of urine

more common in females

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2
Q

what are the subtypes of urinary incontinence

A

stress

urge

mixed

overflow

continuous

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3
Q

what is stress incontinence and what is the most common cause

A

leakage of urine due to increased intra-abdominal pressure such that it overcomes urethral pressure

occurs when coughing, laughing, sneezing, lifting, straining

most commonly caused due to weakness in pelvic floor muscles - commonly seen post-partum

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4
Q

what is urge incontinence and what is the most common cause

A

overactive bladder leading to uninhibited bladder contraction, rising intravesical pressure and subsequent leakage of urine

caused by overactive bladder which can be from a neurological cause, infection, malignancy, idiopathic or medication

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5
Q

what is overflow incontinence and what is the most common cause

A

due to chronic urinary retention such that progressive stretching of the bladder damages nerve fibres - so you get gross dilatation of the bladder leading to a constant dribble of urine

most common cause is BPH

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6
Q

what is continuous incontinence and what is the most common cause

A

constant leakage of urine

due to an anatomical abnormality e.g. bladder fistulae or ectopic ureter

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7
Q

investigations into urinary incontinence

A

mid-stream urine sample to check haematuria and infection

post-void bladder scan

bladder diary

urodynamic assessment

potentially a cystoscopy, MRI, etc.

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8
Q

lifestyle management of urinary incontinence

A

lose weight

reduce caffeine and alcohol intake

avoid drinking excessive volumes of fluid each day

smoking cessation

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9
Q

Conservative management of urinary incontinence

A

3 months pelvic floor exercises

Duloxetine - increases strength of urethral contractions

for urge UI - try anti-muscarinic such as oxybutynin which inhibit detrusor contraction

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10
Q

what drug or class of drugs would be suitable for a patient with Urge UI

A

anti-muscarinics e.g. oxybutynin

inhibit detrusor muscle contraction

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11
Q

mechanism of duloxetine

A

increases strength of urethral contractions - used in stress UI

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12
Q

surgical management of urinary incontinence

A

urge UI - botulinum toxin A injections

stress UI - tension free vaginal tape and equivalent in men

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13
Q

aetiology of bladder cancer

A

most common in >80 yrs

most common in men

develops from the lining of the bladder

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14
Q

subtypes of bladder cancer and the most common

A

Transitional cell carcinoma (most common 80-90% of cases)

Squamous cell carcinoma

adenocarcinoma and sarcoma (both rare)

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15
Q

subtypes of bladder cancer are further divided based on what

A

non-muscle invasive

muscle invasive

locally advanced

metastatic

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16
Q

what are the layers of the bladder wall

A

inner layer = transitional epithelium

2nd layer = connective tissue layer (lamina propria)

3rd layer = muscular layer (muscularis propria)

outer layer = fatty connective tissues

17
Q

risk factors for bladder cancer

A

most important risk factor is smoking

exposure to industrial carcinogens e.g. dyes, etc

schistosomiasis infection (particularly important in SCC)

18
Q

clinical features of bladder cancer

A

most common presenting complaint is painless haematuria

can also present with recurrent UTIs or LUTS

19
Q

most common presenting complaint with Bladder cancer

A

painless haematuria

20
Q

what extra symptoms would locally advanced and metastatic bladder cancer present with

A

locally advanced may present with pelvis pain

metastatic can present with systemic symptoms such as weight loss and lethargy - would also present with other symptoms based on where the metastases is located

21
Q

investigation into suspected bladder cancer

A

urgent cystoscopy - then followed by a rigid cystoscopy for more definitive assessment

tumours will then require biopsy and potential CT and USS

22
Q

what is the main treatment of a non-muscle invasive bladder cancer

A

TURBT - trans urethral resection of bladder tumour

23
Q

management of muscle invasive bladder cancer

A

radical cystectomy - complete removal of the bladder

24
Q

how is urinary diversion done in a patient who has had a radical cystectomy

A

ileal conduit formation (impairs B12 absorption)

or bladder reconstruction