Bisprolol Flashcards
What is the trade name for Bisoprolol ?
Monocor, Zebeta
What are the available dosage forms and strengths of Bisoprolol ?
Tablet 5mg, 10mg
What is the initial dosage of Bisoprolol for hypertension?
2.5-5 mg PO qDay
What is the maximum dosage of Bisoprolol that can be administered for hypertension?
20 mg PO qDay
What is the initial dosage of Bisoprolol for heart failure?
1.25 mg PO qDay
What is the maximum dosage of Bisoprolol that can be administered for heart failure?
10 mg/day
How should Bisoprolol be adjusted in patients with renal impairment?
2.5 mg/day initially if <40 mL/min; titrate slowly and monitor
What is the most common adverse effect of Bisoprolol?
Dizziness (10%)
What are some other common adverse effects of Bisoprolol?
- Insomnia (8%-10%)
- Bradyarrhythmia (9%)
- Upper respiratory infection (5%)
- Diarrhea (4%)
- Rhinitis (4%)
- Arthralgia (3%)
- Cough (3%)
- Dyspnea (2%)
- Nausea (2%)
- Pharyngitis (2%)
- Sinusitis (2%)
- Vomiting (2%)
What is the mechanism of action of Bisoprolol?
Blocks response to beta-adrenergic stimulation; cardioselective for beta-1 at low doses
What is the half-life of Bisoprolol in normal renal function?
9-12 hr
What is the bioavailability of Bisoprolol?
80%
What is the onset of action for Bisoprolol?
1-2 hr
What are some contraindications for Bisoprolol?
- Sinus bradycardia 2°/3° heart block
- Cardiogenic shock
- Overt cardiac failure
- Hypersensitivity
- Sick sinus syndrome without permanent pacemaker
What should be used with caution when administering Bisoprolol?
- Anesthesia/surgery
- Bronchospastic disease
- Cerebrovascular insufficiency
- CHF
- Cardiomegaly
- DM
- Hyperthyroidism/thyrotoxicosis
- Myasthenia gravis
- Liver disease
- Renal impairment
- Peripheral vascular disease
- Use in pheochromocytoma
- IDDM
- History of psychiatric disease
- Pre-existing sick sinus syndrome
True or False: Chronically administered beta-blocking therapy should be routinely withdrawn prior to major surgery.
False
What pregnancy category is Bisoprolol classified under?
C
Is the excretion of Bisoprolol in milk known?
Unknown; use caution
What has been shown regarding Bisoprolol’s effectiveness in black and geriatric patients?
Less effective than thiazide diuretics
What is one benefit of Bisoprolol in the context of hypertension?
Shown to decrease mortality in hypertension and post-myocardial infarction
