Bisc 102 final Flashcards
Evolution by natural selection in three steps
- Variation among individuals
- Heritable variation
- Variation linked to fitness
Asexual reproduction
Reproduction without fertilization or conjugation; Parent passes on 100% of its genes to all its offspring (produces clones); Can be parthenogenesis, fragmentation, budding, vegetative propagation
Sexual reproduction
Occurs through fertilization to produce a genetically novel individual; Each parent passes ~50% of its genes to each offspring; Offspring tend to resemble parents; Internal or external fertilization
Variation in sexual function
Separate sexes; hermaphrodites (simultaneous ex. flowers or sequential ex. some fish that start as female then become male)
Karyotype
A display of the chromosome pairs of a cell arranged by size and shape- homologous pairs have the same staining pattern and centromere position
46 chromosomes in humans (44 autosomes, 2 sex chromosomes) 2n = 46; 18 in carrots; 32 in cats;
1262 in adder’s fern (why so many: a lot would not be useful!)
3 events unique to meiosis
- Synapsis and crossing over during prophase 1 (formation of the synaptonemal complex and genetic rearrangement between nonsister chromosomes) 2. Homologous pairs at the metaphase plate, rather than individual chromosomes 3. Separation of homologs instead of separation of chromatids.
Sources of genetic variation
Crossing-over (= recombination), Independent assortment, Random fertilization
Crossing-over
Exchange of corresponding segments of DNA by non-sister chromatids in a tetrad during Prophase I, producing new combinations of maternal and paternal alleles
Independent assortment
Random alignment of each pair of homologous chromosomes at Metaphase I plate ie. each pair of homologs may orient with either its maternal or paternal homolog closer to a given pole, independently of any other pair of homologs (2^23 possibilities= 8.4 million)
Random fertilization
Which egg of 2^23 possibilities will combine with which sperm of 2^23 possibilities? Any 2 parents will produce a zygote with ~70 trillion (2^23x 2^23) diploid combinations
Advantages of sex
Introduces new combinations of heritable traits in offspring; Introduces new combinations of heritable traits in offspring; Potentially useful in a variable, dynamic environment
Mendelian genetics
The scientific study of how traits are passed on from parent to offspring; The study of heredity
Mendel’s 1st law of heredity
Law of segregation: The two alleles for a heritable trait separate during gamete formation and end up in different gametes
Mendel’s 2nd law of heredity
Law of independent assortment: Each pair of alleles segregates independently of each other pair of alleles during gamete formation
Genotype
The genetic makeup or set of alleles of an organism
Phenotype
The observable physical and physiological traits of an organism which are determined by it’s genetic makeup
Incomplete dominance
The situation in which the phenotype of heterozygotes is intermediate between the phenotypes of individuals homozygous for either allele ex. Rr gives pink flower, when RR is red and rr is white
Co-dominance
The situation in which the phenotypes of both alleles are exhibited in the heterozygote because both alleles affect the phenotype in separate, distinguishable ways ex. blood types IAIB contains both A and B proteins
Sickle cell disease is an example of what kind of phenotypic expression of genotype?
Both codominant and incomplete dominance:
RB cells are codominant (A1A1 normal, A1A2 50% sickcle, A2A2 all sickle) while the individual shows nomal or mild or full diseases symptoms
Heterozygote advantage
Approximately 1/10 African Americans is heterozygous for the sickle-cell allele. This is higher than expected, because sickle cell anemia gives partial protection from malaria
Polygenic inheritance
Multiple genes determine trait; Polygenic characters have near-normal frequency distribution; ex. Human skin colour
Multiplication law
Probability of independent events A and B = (Probability of event A) x (Probability of event B)
Autosomal recessive pedigree
If a condition is recessive (i.e. afflicted individuals have 2 recessive alleles): Homozygous recessive individuals ARE afflicted; ‘Normal’ parents can have afflicted offspring; The condition can appear suddenly or skip generations
Autosomal dominant pedigree
If a condition is dominant (i.e., afflicted individuals have 1 or 2 dominant alleles): Homozygous recessive individuals ARE NOT afflicted; Afflicted offspring have at least one afflicted parent; The condition cannot skip a generation