Bipolar Disorder and Depression Flashcards

1
Q

major depressive disorder (mdd) = __________ depression

A

unipolar

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2
Q

what are some symptoms of mdd/unipolar depression

A
  • chronic depressed mood
  • fatigue
  • low motivation
  • anhedonia
  • changes in appetite and sleep
  • rumination
  • suicidality
  • comorbid w anxiety
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3
Q

what is the lifetime prevalence of mdd

A

approx 15-20%

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4
Q

bipolar disorder = ________ depression

A

bipolar

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5
Q

what do patients cycle between in bpd

A

cycles of mania and depression

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6
Q

for the 3 types of bpd, how are they differentiated

A

depends on the amount of time a person spends in mania and severity of symptoms

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7
Q

what are the differences in the biology of the three types of bpd

A

trick question! there are not necessarily are differences in biological underpinnings

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8
Q

t/f does a bipolar diagnosis stay w them for their whole life

A

true

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9
Q

what type of bpd is the following: the primary symptom presentation is mania (either MORE mania or LESS depressed), or rapid cycling episodes of mania and depression

A

type 1

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10
Q

how rapid are the cycling episodes for bpd type 1

A

rapid daily cycling

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11
Q

what type of bpd is the following: primary symptom presentation is recurrent depression accompanied by hypomanic episodes

A

type 2 bpd

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12
Q

is the state of mania for bpd type 2 heavy, mild, or light

A

it is mild - symptoms aren’t severe enough to cause marked impairment in social or occupational functioning or need for hospitalisation, but sufficient enough to be observed by others

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13
Q

what type of bpd is the following describing: a chronic state of cycling between hypomanic and depressive episodes that do not reach the diagnostic standard for bpd

A

cyclothymic disorder

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14
Q

does cyclothymic disorder have more or less severe symptoms than bpd 1 or 2

A

is has less severe symptoms

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15
Q

describe the characteristics of manic episodes (8)

A
  1. distinct period of abnormally and persistently elevated, expansive or irritable mood lasting 1 week
  2. increased self esteem or grandiosity
  3. decreased need for sleep (eg feels rested after 3h)
  4. flight of ideas or subjective experience that thoughts are racing
  5. more talkative than usual or pressure to keep talking
  6. distractibility (attention too easily drawn to unimportant or irrelevant external stimuli)
  7. increase in goal directed activity (socially, at work or school, or sexually) or psychomotor agitation (moving a lot and quick)
  8. excessive involvement in pleasurable activities that have a high potential for painful consequences (eg engaging in unrestrained buying sprees, sexual indiscretions, or foolish business investments)
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16
Q

what are the conditions for someone to be diagnosed with the manic side of bpd

A

lasting 1 week of mania - it can be shorter but during diagnosis they usually look for longer or if they needed to hospitalize you (if hospital, any duration)

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17
Q

describe the characteristics of depressive episodes (9)

A
  1. depressed mood most of the day
  2. diminished interest or pleasure in all or most activities
  3. significant unintentional weight loss or gain
  4. insomnia or sleeping too much
  5. agitation or psychomotor retardation noticed by others
  6. fatigue or loss of energy
  7. feelings of worthlessness or excessive guilt
  8. diminished ability to think or concentrate, or indecisiveness
  9. recurrent thoughts of death or suicide
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18
Q

what is the % of genetic component affecting bpd

A

70-80%

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19
Q

how many genes causes bpd

A

many, not one single

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20
Q

genetic susceptibility for bpd shares more in common w ____________ than ____________

A

schizophrenia, unipolar (MDD)

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21
Q

when is the onset of bpd

A

post-adolescent/early adult (similar to schiz)

22
Q

% prevalence worldwide

23
Q

what is the difference between the prevalence of bpd in males and females

A

equal prevalence

24
Q

what happens to the illness when you don’t have treatment

A

it gets worse

25
how can mania be triggered
Mania can be triggered: stressful situation (even good stress), lack of sleep <-- upset someone's equilibrium/daily routine, stimulants, life stress (+/-)
26
people with bipolar should have a more ___________ lifestyle
regimented
27
comorbidities of bpd
adhd, anxiety disorder, substance abuse, obesity, and metabolic syndrome (type 2 diabetes, cvd, dyslipidemia)
28
will the comorbidities still happen even if you take medication
yes
29
what are the statistics (%) of people w suicidal thoughts, those who attempted, those who completed
80, 50, 15
30
what are some treatment strategies
mix of mood stabilizers, antipsychotics, and antidepressants, lifestyle changes, psychotherapy
31
commonly prescribed mood stabilizers
lithium and valproate
32
what is the best mood stabilizer
lithium salt (lithium carbonate)
33
what is the mechanism of action of lithium salt
unknown
34
describe pharmacotherapies
combo of several medicines that depend on the symptoms of the patient (mood stabilizers w antidepressants and antipsychotics)
35
describe the suspected MOA of lithium salt/lithium carbonate
appears to block downstream signalling events that occur when dopamine receptors are activated (signalling cascades) - lithium acts inside the cell which blocks the activation of signalling cascades (the signalling comes from the postsynaptic dopamine neuron's receptor sensing the dopamine) which further block dopamine mediated behaviours (?)
36
what are the adverse effects of lithium? (acute (9), chronic (2 key))
acute: * frequent urination (diabetes insipidus) * headache * metallic taste * nausea * vomiting * confusion * shaky hands * thirsty * Dry mouth chronic: - thyroid problems: insufficient thyroid hormone production - kidney toxicity: when kidney func is reduced, people must discontinue lithium
37
what is the therapeutic window of lithium and what is the significance of this towards prescribing care
Lithium is known to have a narrow therapeutic window, this means that the dose needed to treat the disease is close to the dose that causes toxicity. Blood levels of lithium are monitored to make sure people in the safe range
38
what is the anticonvulsant mood stabilizer for bpd
valproic acid (valproate)
39
t/f anticonvulsants DON'T have some mood stabilizing properties
false
40
describe the moa of valproate
- blocks voltage gated Na channels - req to propagate action potentials along the axon - also changes gene expression and increases the amount of gaba; valproic acid opens up the genes and increases the amount of gene expression at many diff genes (one of these is the enzyme that makes gaba)
41
how does the moa of valproate help w bpd
unknown - all we known is that both moa of valproate decrease neuron firing
42
name two other anticonvulsant mood stabilizers
- lamotrigine (depressive mood stabilizer) - carbamazepine (manic mood stabilizer)
43
what are the other applications of lamotrigine & carbamazepine
epilepsy
44
what are the targets of lamotrigine & carbamazepine
blocking glutamate receptors, blocking Ca channels, and others
45
in total, what are the drugs used to treat bpd
- lithium, valproate - lamotrigine, carbamazepine - 2nd gen APS, antidepressants
46
3 factors that bpd is similar to schizophrenia
onset, prevalence, genetics
47
how is bpd similar to depression
symptoms
48
what nt is associated with mania
dopamine
49
t/f can antidepressants be used (in combo w _________) as a pharmacotherapy for bpd
true, in combo with a mood stabilizer or antipsychotic
50
what is a 2nd generation antipsychotic medications
Quetiapine
51
why might 2nd gen antipsychotics be better
you only need to take one drug, quetiapine may be used alone since it seems to have some antidepressant properties for bpd and also be a APS