Bipolar/Depression/Anxiety

Question 1

SSRIs (6) (just name them, brand and generic)

Answer 1

Citalopram (celexa), Escitalopram (lexapro), Fluoxetine (prozac), Fluvoxamine (luvox), Paroxetine (Paxil), Sertraline (zoloft),

Question 2

SSRIs MOA

Answer 2

Inhibits reuptake of serotonin

Question 3

SSRIs AE

Answer 3

GI, sexual dysfunction, HA, insomnia, serotonin syndrome

Question 4

Citalopram

Answer 4

Celexa SSRI, 20-40 mg, QT prolongation

Question 5

Escitalopram

Answer 5

Lexapro SSRI, 10-20 mg, less seizure risk

Question 6

Fluoxetine

Answer 6

Prozac SSRI, 20-60 mg, may be protective against suicide. may cause anorexia?

Question 7

Fluvoxamine

Answer 7

Luvox SSRI, 50-300 mg, somnolence

Question 8

Paroxetine

Answer 8

Paxil SSRI, 20-60 mg, highest rate of sexual dysfunction

Question 9

Sertraline

Answer 9

Zoloft SSRI, 50-200 mg, may cause insomnia OR sedation.

Question 10

SNRIs (3)

Answer 10

Desvenlafaxine (Pristiq), Duloxetine (Cymbalta), Venlafaxine (Effexor)

Question 11

SNRI AEs

Answer 11

Insomnia, nausea, serotonin syndrome, sexual dysfunction

Question 12

Desvenlafaxine

Answer 12

Pristiqu SNRI, (primary active metabolite of venlafaxine). Hyperlipidemia.

Question 13

Duloxetine

Answer 13

Cymbalta SNRI, used in diabetic neuropathy, orthostatic hypotension.

Question 14

Venlafaxine

Answer 14

Effexor SNRI, dose related hypertension. Maybe more effective, but less tolerable?

Question 15

TCAs (5)

Answer 15

Amitriptyline (elavil), Desipramine (norpramin), Doxepin (sinequan), Imipramine (tofranil), Nortriptyline (Pamelor)

Question 16

TCA MOA

Answer 16

Potentiate activity of NE and 5-HT by blocking their reuptake.

Question 17

TCA AE

Answer 17

Anticholinergic, delirium at higher doses, orthostatic hypotension, cardiac conduction delays, wt gain, sexual dysfunction

Question 18

Amitriptyline

Answer 18

Elavil

Question 19

Desipramine

Answer 19

Norpramin, increased risk of death in pts who have a family history of cardiac problems

Question 20

Doxepin

Answer 20

Sinequan

Question 21

Imipramine

Answer 21

Tofranil

Question 22

Nortryipyline

Answer 22

Pamelor, lowest anticholinergic activity

Question 23

MAOI (3)

Answer 23

Phenelzine (Nardil), Selegiline (Emsam), Tranylcypromine (Parnate)

Question 24

MAOI MOA

Answer 24

Increase the concentrations of NE, 5-HT, and DA within the neoronal synapse through inhibition of the MAO enzyme

Question 25

MAOI AE

Answer 25

Postural hypotension, hypetensive crisis.

Question 26

Phenelzine

Answer 26

Nardil, nonselective, mild sedating effects

Question 27

Selegiline

Answer 27

Emsam, reduced MAO-A in the gut, transdermal

Question 28

Tranycypromine

Answer 28

Parnate, nonselective, insomnia, fever, myoclonic jerking.

Question 29

Mixed (3)

Answer 29

Nefazodone (Serzone), Trazodone (Desyrel), Vilazodone (Viibryd)

Question 30

Nefazodone

Answer 30

Serzone, 5-HT2 antagonist and 5-HT reuptake inhibitor BBW: hepatic toxicity. light-headedness, dizziness. female priapism.

Question 31

Trazodone

Answer 31

Desyrel, 5-HT2 antagonist and 5-HT reupatke inhibitor. Sedation, male priapism.

Question 32

Vilazodone

Answer 32

Viibryd, SSRI and 5-HT1A receptor partial agonist.

Question 33

Bupropion

Answer 33

Wellbutrin (NDRI), inhibits NE and DA reuptake pump, nausea, vomiting, tremor, insomnia, dry mouth, skin rxn, seizure (dose related).

Question 34

Mirtazapine

Answer 34

Remeron, 5-HT and alpha2 adrenergic antagonist, anti-histamine effects at low doses, somnolence, weight gain, dry mouth, constipation.