Biotransformation Reactions

Question 1

What Drug Biotransformation Reaction occurred in the following:

Procaine → p-aminobenzoic acid

Answer 1

Inactive Metabolites

Active drug → inactive metabolite

Question 2

What Drug Biotransformation Reaction occurred in the following:

6-mercaptopurine → 6-mercaptopuric acid

Answer 2

Inactive Metabolites

Active drug → inactive metabolite

Question 3

What Drug Biotransformation Reaction occurred in the following:

amphetamine → phenylacetone (deamination)

Answer 3

Inactive Metabolites

Active drug → inactive metabolite

Question 4

What Drug Biotransformation Reaction occurred in the following:

phenobarbital → hydroxyphenobarbital (hydroxylation)

Answer 4

Inactive Metabolites

Active drug → inactive metabolite

Question 5

What Drug Biotransformation Reaction occurred in the following:

Imipramine → desipramine

Answer 5

Metabolites That Retain Similar Activity

Active drug → active metabolite

Question 6

What Drug Biotransformation Reaction occurred in the following:

acetohexamide → L-hydroxyhexamide

Answer 6

Metabolites That Retain Similar Activity

Active drug → active metabolite

Question 7

What Drug Biotransformation Reaction occurred in the following:

Codeine → Morphine

Answer 7

Metabolites That Retain Similar Activity

Active drug → active metabolite

Question 8

What Drug Biotransformation Reaction occurred in the following:

Procainamide → N-acetyl procainamide (acetylation)

Answer 8

Metabolites That Retain Similar Activity

Active drug → active metabolite

Question 9

What Drug Biotransformation Reaction occurred in the following:

Phenylbutazone → oxyphenbutazone (hydroxylation)

Answer 9

Metabolites That Retain Similar Activity

Active drug → active metabolite

Question 10

What Drug Biotransformation Reaction occurred in the following:

Iproniazid → isoniazid

Answer 10

Metabolites with Altered Activity

Active drug → polar metabolite

Question 11

What Drug Biotransformation Reaction occurred in the following:

Retinoic acid → Isotretinoin

Answer 11

Metabolites with Altered Activity

Active drug → polar metabolite

Question 12

What Drug Biotransformation Reaction occurred in the following:

Enalapril → Enalaprilat

Answer 12

Bioactivated Metabolite

Inactive drug → active metabolite

Question 13

What Drug Biotransformation Reaction occurred in the following:

Levodopa → dopamine

Answer 13

Bioactivated Metabolite

Inactive drug → active metabolite

Question 14

What Drug Biotransformation Reaction occurred in the following:

Hetacillin → ampicillin

Answer 14

Bioactivated Metabolite

Inactive drug → active metabolite

Question 15

What Drug Biotransformation Reaction occurred in the following:

Sulfasalazine → sulfapyridine+aminosalicylic acid

Answer 15

Bioactivated Metabolite

Inactive drug → active metabolite

Question 16

What Drug Biotransformation Reaction occurred in the following:

Sulindac → ?active sulfide

Answer 16

Bioactivated Metabolite

Inactive drug → active metabolite

Question 17

What Drug Biotransformation Reaction occurred in the following:

Prontosil → sulfanilamide

Answer 17

Bioactivated Metabolite

Inactive drug → active metabolite

Question 18

What Drug Biotransformation Reaction occurred in the following:

Acetaminophen → NAPQI

Answer 18

Reactive Metabolite

Active drug → reactive metabolite

Question 19

What Drug Biotransformation Reaction occurred in the following:

Malathion → Malaoxon

Answer 19

Reactive Metabolite

Active drug → reactive metabolite

Question 20

What Drug Biotransformation Reaction occurred in the following:

Parathion → Paraoxon

Answer 20

Reactive Metabolite

Active drug → reactive metabolite

Question 21

What Drug Biotransformation Reaction occurred in the following:

Benzopyrene → Reactive

Answer 21

Reactive Metabolite

Active drug → reactive metabolite