Bioterrorism Flashcards
CBRNE mnemomic
chemical, biological, radiological, nuclear, energetic (explosives and incendiary)
chemical has __ onset of sx
rapid
biological agents create __ onset of sx
gradual
describe anthrax bacteria
bacillus anthracis encapsulated aerobi gram + spore former Rod shaped
what are the two toxins anthrax creates?
edema toxin ET and lethal toxin LT
sx of cutaneous anthrax exposure
painless skin lesions over 1-7 days
papules to vesicle to depressed black eschar with local edema
80% recover w/o tx
onset of inhalation anthrax exposure
onset 1 wk but up to 2 mo
Prodrome - viral resp illness
hypoxia, dyspnea with mediastinal widening, or pleural effusion on CXR
88% fatal event even with aggressive tx
sx inhalation anthrax exposure
fever, chills, chest discomfort, SOB, cough, N/V, dizzy, HA sweats, myalgias
signs of anthrax meningitis from inhalation exposure
AMS, fever, HA, N/V, sz, nuchal rigidity
krnig/brudzinski sign
gastrointestinal sx
severe abdominal distress s/s of septicemia
fever, chills, cervical lymphadenopathy, pharyngitis, dysphagia, hoarseness, N/V/D, hematemesis, HA, flushing, red eyes, abdominal pain/swelling etc
anthrax abx tx
1 bacteriocidal agent
(Cipro, levo, moxi, meropenem, impipenem, doripenem, vancomycin)
AND 1 protein synthesis inhibitor: clindamycin, linezolid, doxy, rifampin
anthrax tx if PCN susceptible
for bacteriocidal agent use one of following: Pen G or ampicillin
anthrax additional tx with abx
need good CNS penetration for anthrax meningitis: fluoro + b lactam + protein synthesis inhibitor
anthrax PEP
doxy and Cipro are first line
Sensitive: amoxicillin, Pen VK, clndaymycin
Dose for 60 days
what drug would you consider for anthrax exposure with pregnancy?
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