Biopsychology Flashcards
What is denervation? (Plasticity + recovery from brain trauma)
- Loss of nerve supply. Inactivity and atrophy of muscle fibres.
What is denervation super sensitivity / denervation hypersensitivity? (Plasticity + recovery from brain trauma)
- sharp increase of sensitivity of post-synaptic membranes to a chemical transmitter after denervation, it is compensatory change
What is atrophy? (plasticity + recovery from brain trauma)
- Reduction in size of cells / tissue / organs.
What is synaptic pruning?
- as we age, rarely used connections are deleted and frequently used connections are strengthened.
- 15,000 synaptic connections by 2-3 years of age (Gopnik et al 1999)
What is neural plasticity?
-the brain’s tendency to change and adapt (mould) functionality and physically as a result of exp and new learning
What happens in the brain during recovery?
- process is supported by a number of structural changes:
1) axon sprouting: new nerve endings grow and connect with us damaged areas.
2) reformation of blood vessels.
3) recruitment of homolagous (similar) areas: on the opposite hemisphere to do specific tasks. E.g. if Broca’s area was damaged then an area on the right might take over
Explain how recovery of the brain after trauma is an example of plasticity (increased brain stimulation)
- there is increased brain stimulation, if neurons are damaged, neighbouring neutrons are also affected (works the same for the hemispheres).
- therefore, you need to stimulate the undamaged neighbouring neutrons or healthy hemispheres to aid plasticity
List the evaluations for research on plasticity:
Positive:
- plasticity application
- age and plasticity
- support from animal studies
- the concept of cognitive reserve
Negative:
- negative plasticity
Explain how practical application is a positive evaluation for research on plasticity (neuro-rehab)
- Understanding plasticity has contributed to the field of neuro- rehabilitation.
- Following illness or injury to the brain, spontaneous recovery tends to slow down after a number of weeks, so physical therapy may be required.
- Including movement therapy and electrical stimulation to counter the deficits in motor and/or cognitive function.
- This shows the brain has the ability to fix itself
Explain how negative plasticity is a negative evaluation for research on plasticity
- brain’s ability to rewire can have maladaptive behavioural consequences.
- Prolonged drug shown to result in poorer cognitive function + increased risk of dementia (Medina et al., 2007).
- 60-80% of amputees known to develop phantom limb syndrome.
- unpleasant, painful and thought to be due to cortical reorganisation in the somatosensory cortex (Ramachandran & Hirstein, 1998)
Explain how age and plasticity are related and are a positive evaluation for plasticity research
- brain has a greater tendency for reorganisation in childhood, constantly adapting to new experiences and learning.
- Bezzola et al. (2012) demoed 40 hours of golf training produced changes in neural representation of movement in ppts aged 40-60.
- Using fMRI researchers observed reduced motor cortex activity in novice golfers than controls, suggesting more efficient neural representations after training
Explain how support from animal studies is a positive evaluation for research on plasticity
- Hubel and Wiesel (1963) sewed one eye of a kitten shut and analysing brain’s cortical responses. found that the area of visual cortex associated with the shut eye was not idle but continued to process information from the open eye
Explain how the concept of cognitive reserve supports research on plasticity/recovery
- evidence to suggest person’s educational attainment may influence how well brain adapts after injury.
- Schneider et al. (2014) discovered that more time brain injury patients had spent in education (which was taken as their cognitive reserve), the greater their chances of disability-free recovery (DFR).
- 2/5 of patients studied who achieved DFR had more than 16 years education compared to about 10% who had less than 12
List the features of Eleanor Maguire’s research on plasticity:
- studied brains of LDN taxi drivers (MRI), found more grey matter in posterior hippocampus than in control group.
- part involved with development of spatial and navigational skills.
- LDN drivers take complex test ‘the knowledge’ testing recall of city streets and possible routes.
- positive correlation between how long in job and structural difference
Explain the evaluations of Maguire’s research on taxi drivers (plasticity)
Positives:
- Control group allows us to say that there is a significant difference between taxi drivers and others. (good design).
- Use of scientific, objective measurements (MRI)
- An attempt to study a real world phenomena.
- negative: can’t be sure difference due to ‘knowledge’, were not tested before
What is Broca’s aphasia and what is Wernicke’s aphasia?
- Broca’s aphasia- speech is slow, laborious and lacking of fluency.
- Wernicke’s aphasia- couldn’t understand language, fluent but meaningless- nonsensical words.
- specialised areas associated with lang found in left brain’s hemispheres rather than both- both Broca’s area and Wernicke’s area were found in the left hemisphere
What is the corpus callosum?
- A flat bundle of commissural fibres
Describe the key features of Sperry’s research on split brain
- procedure: ppts asked to perform range of tasks and performance compared with ppts with no interhemispheric disconnection. Blindfolded 1 eye only receiving info.
Results:
- info shown to only one hemisphere only recalled if shown to same one again.
- visual material shown to left can be described in speech and writing, if shown to right ppt denies seeing but able to pick correct object with left hand.
Conclusion: some lateralisation of function between hemispheres
What are the strengths of Sperry’s research on split brain?
- High levels of control.
- Clearly demonstrated the lateralisation of function between the left and right
hemisphere. - Although small sample, it was representative of the people who
have had this operation
What are the weaknesses of Sperry’s research on split brain?
- tasks lack ecological validity- the problems ppts faced in the task would probably not be a problem in real life.
- may not be possible to compare the brains of severe epileptics who have undergone brain surgery to the brains of neurotypical people.
- Only 11 participants which is a small sample to generalise from
List the evaluations of split-brain research:
Positive:
- Demonstrated lateralised brain functions
- strengths of the methodology
Negative:
- Theoretical basis
- issues with generalisation
- differences in function may be overstated
Explain how split-brain research demonstrates lateralised brain functions (positive evaluations)
- pioneering work into the split-brain phenomenon produced impressive and sizeable body of research findings, main conclusions of which the left hemisphere is more geared towards analytic and verbal tasks, whilst the right is more adept at performing spatial tasks and music.
- right hemisphere only produce rudimentary words and phrases but contributes emotional and holistic content to language.
- Left hemisphere = analyser
- Right hemisphere = synthesiser
Explain how split-brain research demonstrates strong methodology (positive evaluation)
- highly specialised and standardised procedures.
- The method used was ingenious – typically participants would be asked to stare at a given point, the ‘fixation point’, whilst one eye is blindfolded.
- image projected would be flashed up for 1/10 of a second, means split brain patient would not have time to move their eye across the image and so spread the information across both sides of the visual field and both sides of the brain.
- Sperry developed a useful and well-controlled procedure based off the original research
Explain how research on split-brain relies on theoretical basis (negative evaluation)
- Puncetti suggested the hemispheres are so functionally different they represent a form of duality in the brain, that in effect we are all two minds and that this is a situation that is only emphasised rather than created in the split brain patient.
- In contrast, other researchers have argued that, far from working in isolation, the two hemispheres form a highly integrated system and are both involved in most everyday tasks
Explain how research on split brain have issues with generalisation (negative evaluations)
- The sample of ppts is unusual.
- only 11 took part in all variations of the basic procedure, all of whom had a history of epileptic seizures.
- has been argued that this may have caused unique changes in the brain that may have influenced the findings.
- Some of ppts had experienced more disconnection of the two hemispheres as part of their surgical procedure than others.
- control group Sperry used, was made up of 11 people with no history of epilepsy, may have been inappropriate
Explain how split brain research may overstate differences in function (negative evaluation)
- One legacy of Sperry’s work is a growing body of pop- psychological literature that overemphasises and oversimplifies the functional distinction between the left and right hemisphere.
- modern neuroscientists would contend that the actual distinction between the 2 hemispheres is less clear-cut and much more messy than this.
- In normal brain many of behaviours typically associated with one hemisphere can be effectively performed by the other when the situation requires it
What are the different ways of studying the brain?
- fMRI / MRI
- EEG
- ERP
- Post-mortem examinations
Explain how fMRI scans work to show brain activity (ways of investigating the brain)
- 3D scan providing structural and functional information.
- Shows changes in brain activity using strong magnetic field and radio waves.
1. More oxygenated blood flows to active areas of the brain.
2. Molecules in oxygenated blood respond differently to a magnetic field than those in deoxygenated blood.
3. More active areas of the brain can be identified.
Extra info:
- takes pictures of ‘slices’ of your brain (horizontal slices) to make 3D image.
- interrupts magnetic field -> however very subtle changes -> not threatening.
- it is accurate to within 1-2mm in the brain
What is the haemodynamic response?
- rapid delivery of neural activity with oxygenated blood.
What are the strengths of fMRI scans (ways of investigating the brain)?
- Provides high resolution moving picture of brain activity. This means patterns of activity can be compared rather than just the physiology of the brain.
- non-invasive/virtually risk free.
- Does not rely on radiation
What are the weaknesses of fMRI scans (investigating the brain)?
- Poor temporal resolution- 5 second time-lag behind the image on the screen and the initial firing of neuronal activity.
- Expensive and can only capture a clear image if the person stays still.
- only measures blood flow in the brain. It cannot home in on activity of individuals neurons
What are the uses of EEGs (ways of investigating the brain + sleep studies)?
- Commonly used in sleep studies
- studies depression and schizophrenia. A meta-analysis by Boutros et al. (2008) showed patients suffering from schizophrenia displayed abnormal EEG wave patterns compared to controls.
- Abnormal EEGs have also been identified in patients suffering from anorexia nervosa.
- EEGs can be used as a diagnostic tool (potentially)
What are the strengths of EEGs (different way of investigating the brain)
- Invaluable in the diagnosis of conditions such epilepsy.
- Contributed to research into ultradian rhythms of sleep.
- Extremely high temporal resolution-can accurately detect brain activity at a resolution of a single millisecond
What are weaknesses of EEGs (ways of investigating the brain)?
- main drawback lies in generalised nature of the information received (1000s of neurons)
- Not useful for pinpointing exact source of neural activity and does not allow researchers to distinguish between activities originating in different but adjacent locations
What are the uses of Event-related potentials (ERPs)?
- ERPs record activity in response to a stimulus introduced by the researcher.
- All extraneous brain activity from the original EEG recording is filtered out leaving only those responses that relate to the specific stimuli.
- Milner et al. (2000) found people with phobias greater amplitude of ERP in response to images of the object they feared
What are the strengths of ERPs (ways of investigating the brain)?
- Much more specificity to the measurement of neural processes than raw EEG data.
- Excellent temporal resolution.
- Researchers identified many different types of ERP and describe precise role of cognitive functioning.
- P300 component involved in allocation of attentional resources and maintenance of working memory
What are the weaknesses of ERPs (ways of investigating the brain)?
- Lack of standardisation in ERP methodology between different research studies which makes it difficult to confirm findings.
- To establish pure data, background noise and extraneous material must be completely eliminated
Explain what postmortem is and its uses (ways of investigating the brain)
- Post-morgen examinations involve dissecting (cutting up) the brain of a person who has died.
- This allows researchers to physically look at the internal structure of the brain.
- uses: if person had medical condition, post-Mortem could show structural abnormalities that could explain their condition.
- e.g. study by Brown et al (1986), showed that patients who had suffered from schizophrenia had enlarged ventricles in their brain
What are the strengths of post-Mortem (ways of investigating the brain)?
- provides foundation for early understanding of key processes in the brain. Broca and Wernicke both used post-mortem studies to establish links between lang and the brain.
- Improves medical knowledge and helps generate hypotheses for further study
What are the weaknesses of post-Mortem (ways of investigating the brain)?
- Causation an issue with these investigations -> observed damage may not be linked to the deficits under review but some other trauma or decay.
- Ethical issues -> patients not able to give consent.
- E.g. case of HM who lost ability to form memories and was not able to provide consent
What are the major sub-divisions of the human nervous system?
- Peripheral NS (PNS)
- Semantic nervous system (SNS)
- Automatic nervous system (ANS)
- Sympathetic nervous system (antagonistic)
- Parasympathetic nervous system (antagonistic)
- CNS
- Spinal cord
- Brain
Explain the role of the brain in the nervous system
- main job to ensure life is maintained.
- Many parts of the brain, some of which are concerned with vital functioning and others which are involved in processes such as problem solving and higher order thinking.
- Involved in higher functioning + psychological processes