BiomechIV-test1 Flashcards
What is the biomechanical triad:
A) muscle, skeleton, joints
Seven Parts of Typical Long Bones?
A) Diaphysis, Metaphysis (2), Epiphyseal Plates (2), Epiphysis (2)
What parts are paired?
Metaphysis, epiphyseal plates, epiphysis
What parts are cartilage?
Epiphyseal plates (place of cell proliferation)
What part results in longitudinal growth and when does this occur?
A) Proliferation of chondrocytes at epiphyseal plates
B) occurs in children before physis is closed and cartilage is replaced with bone
Other names for shaft and epiphyseal plate?
A) Shaft: diaphysis and body
B) Epiphyseal plate: plates (in children), physis or lines (in adults)
What is the difference between epiphysis and apophysis?
A) Epiphysis: primary site of bone growth. Ex: physis
B) Apophysis: secondary site of bone growth. Accessory physis for tubercles, tuberosities and epicondyles.
Where is subchondral bone located?
A) Located deep (immediately adjacent) to articular cartilage and is part of the metaphysis
What type of bone is subchondral bone?
A) Is cancellous (spongy) bone
Does subchondral bone absorb shock?
Yes, it is responsible for transferring loads to the diaphyseal cortex (diaphysis). It forms an intermediate zone between articular cartilage and the cortical bone providing protection to both.
Is subchondral bone vascular?
yes
How do nutrients get to deepest layers of cartilage that is next to subchondral bone?
Subchondral vessels supply the adjacent deep transition zone of articular cartilage while diffusion from
nearby vessels in the periosteum and synovial membrane contribute to the delivery of nutrients to the
peripheral transition zones between articular and intra-articular cartilage.
What is the effects of degenerative arthrosis on subchondral bone?
A) Increased calcification leads to increased rigidity B) increased thickness leads to increased rigidity and impedes the flow of blood in the metaphysis leading to
further degeneration C) sclerosis on xrays- known as subchondral sclerosis or eburnation D) decreased shock absorption
What is found in the joint/synovial cavity? And how much?
A) Synovial fluid rich in GAGs especially hyaluronic acid B) enough to form a film C) Synovial fluid is normally a transudate of blood coursing through capillaries of the synovial membrane
with addition of hyaluronic acid secreted by intimal cells of the synovial membrane
What makes synovial cavity slippery?
A) Synovial fluid. It is very viscous and slippery
What does GAG stand for?
glycosaminoglycans
Hyaluronic acid is the most important component of synovial fluid other than water. List 4 functions of synovial fluid?
Shock absorption, lubrication, supply nutrition, waste product removals
What produces synovial Fluid?
Synovial fluid is secreted by the intima of the synovial membrane
Name the 2 layers of synovial membrane.
A) Intima (innermost layer)
B) Subintima= connective tissue (thicker outer layer)
Which synovial layer is very thin, composed of secretory epithelioid cells and does not contain blood vessels
or nerves and is nearest the joint cavity?
intima
Which layer is thicker, vascularized, innervated, and connected to fibrous capsule, and is composed of
adipose, fibrous or elastic connective tissue?
subintima
What is the significance of fenestrated capillaries in subintima of synovial membrane?
Fenestrated capillaries allow increased fluid exchange, allowing nutrients in and waste out.
What type of fibrous CT predominates in fibrous capsule?
Dense irregular connective tissue
What are dissectible thickenings of fibrous capsule?
A) Not exactly sure of answer.
B) Extra Capsular or Capsular ligaments that function to reinforce sites of mechanical stress
What is an extracapsular ligament?
A) Ligament found outside the joint that is far more important for static support than intra-capsular ligaments
What fibers attach the capsule, ligaments, and tendons to bone?
A) Sharpeys fibers
What are sharpeys fibers composed of?
A) Collagen fiber bundles that intermingle with the collagen fiber of bone
What is wolffs law?
A) Bone forms in response to stress forces on that bone/landmark B) Bone responds to external stress. With more tension on the bone the more bone will be laid done
What do fibroblasts do?
A) They form collagen fibers in connective tissue, which are oriented in response to the direction of stress
applied to the tissue B) no stress on collagen causes random orientation C) fibroblasts are responsible for scarring in the CT.
Is the capsule innervated and vascularized?
A) Yes (both capsulated and non capsulated)
What are the two types of tissue that are the most vascularized in the extremities?
A) Bone and muscle B) increased vascularization leads to increased bruising and bleeding with injury
Define bursa.
A) Synovial membrane lined extra-capsular pouch/pocket that can and cannot communicate with joint
cavities, allowing smoother joint movement.
. Give example of bursa that do and do not communicate with joint cavities.
A) Communicating: suprapatellar and popliteus bursae
B) noncommunicating: pre-patellar and pes anserine bursae
What effects does internal derangement/ injury of a joint have?
A) May lead to swelling of bursae that connect to the joint
What is the function of bursae?
A) They reduce friction between layers of tissue
What is the function of synovial sheaths that surround tendons?
A) They enhance gliding through restricted spaces. Ex: carpal tunnel
What cell type predominates in articular and intra articular cartilage?
A) Water is a main component of both, followed by collagen then GAGs.
What are the major functions of GAGs and collagen?
A) GAGs are hydrophilic (sponge like) and resist compressive forces whereas collagen resists expansion of cartilage, traction and shearing forces.
What direction is collagen oriented at the surface and deeper inside joints? What is this significance of this?
A) Collagen is oriented perpendicular to the joint surface in deeper layers and parallel to joint surfaces at the superficial layers (to resist shear forces that would otherwise rip off the surface tissue when joint surfaces rub on each other.)
Are all articular surfaces lined by hyaline cartilage?
A) Most joints are lined by hyaline cartilage
Which 3.5 surfaces are not line by hyaline cartilage?
Acromioclavicular joint, Sternoclavicular joint, and Temperomandibular joint + 1⁄2 SI joint
Name the most important GAGs in cartilage.
Chondroitin sulfate and glucosamine sulfate.
Know that sulfated GAGs are important. Why?
A) They enhance cartilage proliferation and healing
What cartilage changes occur with degenerative arthrosis?
A) Uneven wear pattern of cartilage and thinning
How would you characterize the normal chondrocyte population?
A) Not sure but: a recycling population of cells that are responsible for maintenance and repair of cartilage matrix.
B) Chondrocytes are flattened along the joint surface organized in chains parallel to articular cartilage and are round in shape in deep parts of the cartilage oriented perpendicular to the articular surface.
C) In normal adult cartilage there is no further mitosis and growth subsides.
What changes in cartilage occur in the aging population?
A) Chondrocyte population decreases resulting less fluid exchange to the tissue. B) Thus the rate and quality of proteoglycan production is also reduced leaving potential for repair and
regeneration of articular cartilage to diminish.
What is boundary lubrication and how does it occur at joints surfaces?
A) Boundary lubrication is like teflon. It is when synovial fluid glycoproteins bind to cartilage surfaces to create a slippery surface.
Is it effective at high or low compressive/shear loads?
A) Boundary lubrication is only effective when exposed to small loads and fails as a lubricant under high
loads
What is hydrostatic lubrication and how does synovial fluid move in/out of cartilage?
A) Hydrostatic lubrication also referred to as fluid film lubrication occurs when the interstitial fluid is squeezed out of the articular cartilage under compression and forms a viscous slippery fluid interface that separates and protects adjacent cartilage surfaces from damage due to compressive and shear stress.
B) Is good under high compressive loads but requires that the cartilage deform like a sponge
Why is rapid pressure oscillations bad and slow pressure fluctuations good?
A) Rapid oscillations reduces the cartilage proteoglycan water holding capacity. With less fluid being squeezed out when under high loads, there is a resultant increase in friction and accelerated wear and tear of articular surfaces as well as sustained pressure on cartilage.
B) Tissue also becomes dampened due to progressive loss of fluid C) Rapid oscillations/ no oscillations are bad because they decrease fluid exchange and cause cartilage to be
starved of nutrients
Note that most slow pressure oscillations occur with normal joint movements.
A) Pressure oscillations found in normal ADLs.
B) Slow pressure fluctuations are good because it allows fluid exchange.
What produces fast oscillations?
A) Vibratory tools, motor vehicles, repetitious activity
How does lubrication change with degenerative arthrosis? Explain.
A) Cell population declines (natural process that occurs while you age and as tissue is damaged) B) GAGs decrease, but serous fluid increases C) Lubrication declines D) Calcification occurs
Name 4 joints with intra articular cartilages. Which one of the four has hyaline articular cartilage?
A) AC (early 20s) SC, TMJ and ulnocarpal. Disc has hyaline intra articular cartilage
What are the other 3 joints lined by?
A) Fibrocartilage
List 5 functions of intra articular cartilage.
A) Increased shock absorption, increased congruency, increased stability, decreased friction, increased motion
Are intra articular cartilage innervated or vascularized? If so, what parts?
A) Yes.
B) The outer transition w/ capsule is innervated for proprioception and nociceptors C) the outer 1/3 of the cartilage is vascularized the inner 2/3 is not vascularized and receives fluid via
diffusion
How do the collage fibers and blood supply change with aging? What does this lead to?
A) As we age collagen fibers are laid down in a more haphazard fashion and blood supply to the tissue progressively decreases. This leads to degeneration of joints over time due to lack of nutrients and proper waste removal.
What is the role of muscles and their tendons in the support of joints?
A) They provide dynamic support for the joint
What is dynamic stability?
A) The ability for muscles and tendons to support a joint externally. B) Is active protection by joint motion and muscle contraction called negative work and is the most
important factor in sparing synovial joints from excessive loading.
What is proprioception?
A) Awareness of a joint/muscle/tissue in space.
How does lack of muscle support and balance lead to joint injury and degeneration?
A) Lack of muscle causes inappropriate or uneven where on articular cartilage causing rapid degeneration/ joint injury. It may also lead to bone on bone joint interaction causing intense pain
B) abnormal ligament or bone structure results in delivery of excessive force to a joint; this requires more counteracting muscle effort leading to premature/excessive muscle fatigue in an attempt to absorb shock/ decelerate involved part.
C) As muscle fatigues bone fracture and joint injury increase due to increased frequency of unguarded unexpected movement when muscles are to week or unprepared to accommodate load.
D) The force applied to these weakened joints is often within normal limits but the force may cause injury without proper dampening effects of muscle.
Popliteus Origin
ORIGIN: As the most proximal member of the deep posterior compart-ment of the knee it arises from the lateral aspect of the lateral femoral condyle, adjacent arcuate ligament and posterior capsule; the popliteofibular ligament forms along its anterolateral margin
Popliteus Insertion
INSERTION: It courses obliquely inferomedially to insert on the posterior aspect of the proximal tibia above the popliteal/soleal line; it also attaches to the lateral meniscus as it crosses lateral to medial
Popliteus innervation
INNERVATION: Tibial n (L4-S1)