Biologics Flashcards
1
Q
What wasa the highest grossing drug in the world in 2019?
A
Humira
2
Q
What was the first biologic for rheumatoid arthritis (RA)?
A
Infliximab
3
Q
Name a PEGylated anti-TNF-a agent?
A
Certolizumab Pegol
4
Q
What is the difference between the PEGylated anti-TNF-a agent and the other anti-TNF-a agents?
A
Pegylated anti-TNF-a (certolizumab) has no crystallisable frgament (Fc) domain.
5
Q
Name a TNF-a inhibitor approved for plaque psoriasis?
A
Etanercept
6
Q
How is etancerpt different from adalimumab and infliximab.
A
Etanercept, a fully soluble, human dimeric fusion protein form of the p75 receptor that inhibts TNF-a by blocking its interaction with cell-surface TNF receptors
