Biological therapy for Schizophrenia

Question 1

What is the most common treatment for SZ?

Answer 1

Antipsychotics

Question 2

What are typical antipsychotics?

Answer 2

First generation of drugs for SZ, and they work as dopamine antagonists.

Question 3

What is an example of a typical antipsychotic, and how is it administered?

Answer 3

• Chlorpromazine.
• Can be taken as a tablet, syrup or injection.
• Dosage is gradually increased to a max of 400 to 800mg.

Question 4

What does it meann by the drug being a dopamine antagonist?

Answer 4

They block dopamine receptors in the brain synapses, reducing the action of dopamine. This can help to reduce symptoms such as hallucinations.

Question 5

What are atypical antipsychotics?

Answer 5

They were developed after typical ones. They often target a range of neurotransmitters such as dopamine or serotonin.

Question 6

What are 2 examples of atypical antipsychotics?

Answer 6

Clozapine and Risperidone

Question 7

Briefly describe clozapine

Answer 7

• A treatment for SZ when others failed.
• People taking it, have to have regular blood tests to ensure they are not developing agranulocytosis.
• Typically 300-450 mg a day.
• Binds to dopamine receptors as well as serotonin and glutamate.

Question 8

Briefly describe respiridone

Answer 8

• Doesn’t have serious side effects like clozapine.
• Can be taken as a tablet, syrup or injection and lasts for around 2 weeks.
• Is believed to bind to dopamine and serotonin receptors.