biological membranes Flashcards
What are all cell & organelle membranes composed of?
Phospholipid bilayer
What are the 3 main functions of a cell membrane?
- provide a partially permeable membrane
- site of chemical reactions
- role in cell communication
Why is the fluid-mosaic model described as a ‘mosaic’?
There is a mixture of phospholipids, proteins, glycoproteins, and glycolipids that the membrane is made of
Why is the fluid-mosaic model described to be ‘fluid’?
The phospholipids align as a bilayer due to the hydrophilic heads being attracted to water and the hydrophobic tails being repelled by water, the fluidity is maintained by cholesterol
What are the 2 types of proteins in the cell surface membrane?
Extrinsic & intrinsic
What are the functions of extrinsic proteins?
- provide mechanical support
- make glycoproteins or glycolipids
- cell recognition, as receptors
What are intrinsic proteins?
Protein carriers or channel proteins which are involved in the transport of molecules across the membrane
What are protein channels?
Proteins that form tubes that fill with water to enable water-soluble ions to diffuse through the membrane
What are carrier proteins?
Proteins that bind with other ions and larger molecules, such as glucose and amino acids, and change shape to transport them to the other side of the membrane
What is the function of cholesterol?
maintains the fluidity of the membrane
How does temperature affect the structure & permeability of the membrane?
High temperature increases the kinetic energy of the phospholipids so that they move even more, this increases the fluidity of the membrane, therefore increasing the permeability which means that the structure can start to break, which makes it easier for particles to move across the membrane. If the temperature is too high, it can denature the carrier & channel proteins in the membrane
How can solvents affect membrane structure & permeability?
Organic solvents e.g. alcohol, dissolve the phospholipid bilayer in membranes, this damage causes the fluidity of the membrane to increase and they become more permeable
What are the 6 key modes of transport into and out of cells?
- simple diffusion
- facilitated diffusion
- osmosis
- active transport
- endocytosis
- exocytosis
What is simple diffusion?
The net movement of molecules from an area of higher concentration to an area of lower concentration until equilibrium is reached - this process does not require ATP, for molecules to diffuse across the membrane they must be lipid soluble & small
What is facilitated diffusion?
A passive process, down the concentration gradient, through proteins. The movement of ions & polar molecules, which cannot simply diffuse, can be transported across membranes by facilitated diffusion using protein channels & carrier proteins