biological explanations Flashcards
Rakic et al
low levels of dopamine in the prefrontal cortex which would affect negative symptoms.
Curran et al
amphetamines increase dopamine and worsen schizophrenia. Support for dopamine hypothesis.
McCutcheon et al
post mortem have consistently found raised levels of glutamate in several brain regions. Other explanations for dopamine.
Gottesman
family studies on schizophrenics. If parents suffer 4.6% chance of also developing it.
Sekar et al
specific types of C4 gene found in schizophrenics. Plays a role in synapse pruning which can lead to schizophrenia.
Gottesman + Sheilds
concordance rates for schizophrenia in MZ twins 48% compared to 17% DZ twins.
Tienair et al
adoption studies where adopted did develop schizophrenia
Conrad et al
anatomical changes in hippocampus. May influence dopamine in basal ganglia which affects information processing in pre frontal cortex. Support for brain structures.
