Biological Explanations Flashcards
Gottesman
Responsible for large scale study of the probability of schizophrenia onset based on genetic similarity.
What are candidate genes?
Genes specifically linked to the onset of schizophrenia
There are 108 (rounded down 100)
Genes identified with being correlated with schizophrenia
What problem is there with a genetic explanation that has to do with monodzygoticism
If there’s a 100% genetic similarity, shouldn’t the concordance rate also be 100%?
Neural c_________ are what?
Neural correlates are any activities in the brain’s structure or chemistry that’s correlated with in this case schizophrenia.
What neurotransmitter is associated with schizophrenia?
Dopamine, the dopamine hypothesis
Schizophrenics have specific brain _______
Abnormalities
High ________ in the ________
Dopamine excess in the metholimbic system.
Dopamine excess in the subcortex (metholimbic system) is associated with ______
Positive and negative symptoms
The sub cortex is the central area of the brain and over activity is associated with h__________ and s________ p________
Hallucinations and speech poverty
Speech poverty might be explained because of the _________ being near the subcortex.
Broca’s area
Low levels of dopamine in the p_____ c______ is associated with n___________ s________
.Prefrontal cortex
.negative symptoms
A problem with the dopamine hypothesis is that it doesn’t explain ________
Why some have dopamine excess/poverty.
The dopamine hypothesis however is a positive because its t________ are widely applicable and affordable.
Treatments
Gottesman
. Study of family genetics
. 45% concordance for MZ and 17% for DZ
. The more similar the genetics the greater the onset risk.
A limitation of the biological approach is it i_________ the effect of the _________
It ignores the effect of the environment
Mesocortial pathway dysfunction = __________ symptoms
Negative
Mesolimbic system dysfunction = _________ symptoms
Positive
