Biological basis of behavior and addiction Flashcards
physiologic responses that occur more or less unconsciously when the brain detects situations
emotion
the conscious experience resulting from these emotions
feeling
some stimuli evoke emotions automatically
emotional competence
What are roles of the limbic system?
emotional behavior
memory
integration of homeostatic responses
sex
motivation
important in feelings of pleasure and may be critically important in addiction
nucleus acuumbens
learn to associate predictive stimuli with danger, harm, or pain
conditioned fear
what is required for fear conditioning?
amygdala
response of fear is the HT releasing CRF to release cortisol from adrenals in order to
suppress inflammation
catabolic state
heighten arousal
survival response
anxiety is …
triggered in the absence of threatening stimulus
Who might have an enlarged amygdala?
PTSD pts
What two spots are able to generate new neurons later in life?
hippocampus and olfactory bulb
implicit memory includes
unconscious, perception and recall
Things learned in a happy state are better recalled in..
a happy state
pts with hippocampus damage will retain..
while lacking…
conditioned response to fearful stimuli
declarative memory of stimuli (lack conscious recall)
a brief high frequency train of stimuli (tetanus) increases the slope of the EPSPs in the target hippocampal neurons
LTP - long term potentiation
NMDA antagonists disrupt some aspects of…
spatial memory
amphetamine and cocaine increase…
dopaminergic neurotransmission
What may be the earliest clinical sign of subfrontal meningioma?
anosmia
inappropriate use of a drug for a non medical purpose
drug abuse
uncontrolled and compulsive use of a drug
addiction
increased dose required for the same effect
tolerance
What group of drugs have the highest abuse potential?
schedule 1
no accepted medical use and high potential for abuse
schedule I
cocaine, methamphetamine, methadone, oxycodone, methylphenidate are all
schedule II
