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Pharma > Biologic DMARDs > Flashcards

Biologic DMARDs Flashcards

1
Q

Which biologic drug targets TNF-alpha and is commonly used in rheumatoid arthritis?

A

Infliximab

Example sentence: Infliximab is a TNF-alpha inhibitor.

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2
Q

What is the mechanism of action of rituximab in treating rheumatoid arthritis?

A

B-cell depletion

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3
Q

Which biologic drug is a fusion protein that inhibits the binding of CD80/86 to CD28, thereby blocking T-cell activation?

A

Abatacept

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4
Q

Which interleukin is targeted by the biologic drug tocilizumab?

A

IL-6

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5
Q

Name a biologic drug that targets IL-17A in the treatment of ankylosing spondylitis.

A

Secukinumab

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6
Q

Which biologic agent is an IL-1 receptor antagonist used in the management of rheumatoid arthritis?

A

Anakinra

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7
Q

What is the primary indication for the use of ustekinumab in rheumatology?

A

Psoriatic arthritis

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8
Q

Which biologic drug targets IL-12 and IL-23 and is used in the treatment of psoriatic arthritis?

A

Ustekinumab

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9
Q

What is the mechanism of action of etanercept in treating rheumatoid arthritis?

A

TNF-alpha inhibition

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10
Q

Name a biologic agent that targets IL-23 specifically and is used in the treatment of psoriatic arthritis.

A

Guselkumab

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11
Q

Which biologic drug targets B-lymphocyte stimulator (BLyS) and is used in systemic lupus erythematosus?

A

Belimumab

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12
Q

What is the primary adverse effect concern associated with the use of TNF inhibitors like adalimumab?

A

Increased risk of infections

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13
Q

Name the biologic drug that targets IL-6 receptor and is used in giant cell arteritis.

A

Tocilizumab

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14
Q

Which biologic agent is a fully human monoclonal antibody that targets TNF-alpha, used in rheumatoid arthritis?

A

Adalimumab

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15
Q

What is the primary therapeutic target of the biologic drug ixekizumab?

A

IL-17A

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16
Q

Name the biologic agent used in rheumatoid arthritis that depletes B cells by targeting CD20.

A

Rituximab

17
Q

Which biologic drug is used in rheumatoid arthritis and targets IL-1 beta?

A

Canakinumab

18
Q

What is the common adverse effect associated with biologic drugs targeting IL-17, like secukinumab?

A

Increased risk of fungal infections

19
Q

Name the biologic agent that targets both IL-12 and IL-23 and is used in the treatment of psoriatic arthritis.

A

Ustekinumab

20
Q

Which biologic drug used in rheumatoid arthritis is known for its rapid onset of action and TNF inhibition?

A

Certolizumab pegol

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