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Musculsk/rheum pharmacology > Biologic DMARDS > Flashcards

Biologic DMARDS Flashcards

1
Q

Structure of Abatacept?

A

-fusion protein: human CTLA4/IgG1 Fc fragment

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2
Q

MOA of Abatacept?

A
  • binds CD 80 &86

- prevents T-cell co-stimulatory signal engaging with CD 28

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3
Q

Structure of Adalimumab?

A

-TNF-alpha monoclonal Ab

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4
Q

MOA of Adalimumab?

A
  • binds TNF-alpha

- blocks interaction with p55 & p75 cell surface receptors

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5
Q

Structure of Anakinra?

A

-recombinant human IL-1 receptor antagonist

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6
Q

MOA of Anakinra?

A

-competitively inhibits IL-1a and IL-1b, binding to IL-1 type receptor

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7
Q

Structure of Certolizumab pegol?

A

-Fab fragment of TNF-a Ab

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8
Q

MOA of certolizumab pegol?

A

-neutralizes membrane associated and soluble human TNF-a

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9
Q

Structure of Entercept?

A

-extracellular ligand binding portion of human p75 TNF receptor linked to part of a human IgG Fc

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10
Q

MOA of Entercept?

A
  • endogenous p75 acts as a TNF antagonist,

- binds to and inactivates TNF but does not effect production or serum levels of TNF

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11
Q

Structure of Golimumab?

A

-human dervied TNF-a Ab

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12
Q

MOA of Golimumab?

A

-binds to and neutralizes both soluble and transmembrane TNF-a

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13
Q

Structure of Infliximab?

A

-chimeric mouse/human IgG1k monoclonal Ab against TNF-a

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14
Q

MOA of Infliximab?

A

-binds to and neutralizes both soluble and transmembrane TNF-a

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15
Q

Structure of Rituximab?

A

-chimeric monoclonal Ab against B-lymphocyte CD-20 receptor.

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16
Q

MOA of Rituximab?

A
  • Fab binds CD20

- Fc recruits immune effector functions to mediate B cell lysis

17
Q

Structure of Tocilizumab?

A

-humanized IL-6 receptor-inhibiting monoclonal Ab

18
Q

MOA of Tocilizumab?

A

-binds to both soluble and membrane bound IL-6 receptors and inhibits signaling

19
Q

Which drugs increase the likelihood of malignancy?

A
  • Adalimumab
  • Certolizumab
  • Entercept
  • Golimumab
  • Infliximab
20
Q

Which drugs have reported risks of CHF, hypotension, angina, or dysrhythmias?

A
  • Adalimumab
  • Golimumab
  • Rituximab
  • Infliximab
21
Q

What drugs have reported blood dyscrasias?

A
  • Anakinra
  • Certolizumab
  • Rituximab
  • Toxilizumab
22
Q

Which drugs may cause a lupus-like syndrome?

A
  • Adalimumab
  • Certolizumab
  • Entercept
  • Infliximab
23
Q

Which drug may cause stephens Johnson’s or TEN?

A

-Rituximab

24
Q

Which drug contains maltose?

A

-Abatacept

25
Q

Which drug(s) do women need to be on BC for?

A

-rituximab

do not need to get pregnant for four-six months after treatment

26
Q

For which drugs to pts needs LFTs?

A
  • Golimumab
  • Infliximab
  • Toxilizumab

Musculsk/rheum pharmacology (1 decks)

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