Bioinformatics

Question 1

What do SNP arrays measure?

Answer 1

Known, common SNPs - Genetics

Question 2

What type of mutation (silent, nonsense, missense) is sickle cell anaemia

Answer 2

Non-conservative missense

Question 3

What is a manhatton plot used for

Answer 3

Genome wide association studies (GWAS)

Question 4

What does Sanger sequencing measure

Answer 4

can identify new or novel mutations
however, small scale

Question 5

What do whole genome and whole exome sequencing measure

Answer 5

can identify brand new mutations like sanger sequencing, but on a genome-wide scale
Whole exome sequencing more cost-effective but limited to protein coding region

Question 6

What is RNA sequencing used for?

Answer 6

To measure the influence of disease or the environment on a given sample
e.g. Cigarette smoke exposure