Biohcem UWorld - Misc

Question 0

Where does drug detox and the synthesis of steroid hormones occur in the cell?

Answer 0

SER

Question 1

Difference between free ribosomes and those bound to RER

Answer 1

Free ribosomes make proteins used in cytosol or orgnelles. Ribosomes bound to RER make proteins bound for the secretory pathway

Question 2

How do pts with essential fructosuria metabolize fructose?

Answer 2

Fructose can go to glycolysis and F-6-P via hexokinase

Question 3

Biotin deficiency

Answer 3

Biotin is a cofactor for carboxylations that add 1 Carbon:

• pyruvate carboxylase (pyruvate to oxaloacetate)
• Acetyl CoA carboxylase (acetyl CoA to malonyl CoA)
• Propiony CoA caroxylase (propionyl CoA to methylmalonyl CoA)

Deficiency caused by antibiotics or excessive eating raw egg whites (avidin).

Dermatitis, alopecia, enteritis.