Biogenic Amine Transmitters

Question 1

Name the biogenic amine transmitters

Answer 1

Dopamine, norepinephrine, epinephrine, histamine, serotonin.

Question 2

Name the three catecholamine and their amino acid precursor?

Answer 2

Dopamine, norepinephrine and epinephrine

Tyrosine is the common amino acid precursor

Question 3

What is the two step pathway that produces dopamine?

Answer 3

Tyrosine-(tyrosine hydroxylase)->Dopa-(DOPA decarboxylase)->Dopamine

Question 4

What loads dopamine?

Answer 4

The vesicular monoamine transpoter (VMAT). The first vesicle loader discovered

Question 5

How is DA catabolized?

Answer 5

Monoamine oxidase -MAO and catechol O-methytransferase (COMT) break down dopamine. Inhibitors of both of these enzymes are anti-depressents. Because they leave more dopamine in the synaptic cleft

Question 6

How is DA removed from the synaptic cleft?

Answer 6

By the DA transporter (DAT), which is present on glial cells and neurons.

Question 7

How to coke and amphetamine work

Answer 7

Inhibit DAT, so that dopamine stays in the synaptic cleft . Amphetamine action is a little different but the net result is a rise in

Question 8

What types of channels does dopamine bind too?

Answer 8

Only metaboptropic channels

Question 9

What is the neurological basis of parkinson’s?

Answer 9

loss of dopamine neurons in the substantial nigra