Biochemistry of the LIver Flashcards
Name the plasma proteins from smallest to largestq
Albumin
Alpha globulins
beta globulins
gamma globulins
Give two example of alpha globulins
ceruloplasmin
retinol binding protein
what does retinol binding protein transport
vitamen A
name two beta globulins
transferrin
fibrinogen
what does transferrin transport
iron
what is fibrinogen
inactive form of fibrin
what is the most abundant plasma protein
albumin
what plasma protein is the main determinent of oncotic pressur
albumin
what stimulates albumin production
insulin
how is iron stored in cells
as ferritin
what plasma protein transports copper
ceruloplasmin
what vitamins are stored in the liver
A
D
B12
what is cholesterol an important precursor for
bile acids
steriods
vitamin D
what is required to synthesize cholesterol
acteyl coA
NADPH
ATP
what is the rate limiting enzyme in cholesterol synthesis
HMG coA reductase
What does HMG coA reductase synthesis
mevalonic acid
Name the steroids produced from cholesterol
corticosteroids - adrenal cortex
androgens- testis
estrogens- ovary
what enzyme catalyses the first step of metabolism in the liver
cytochrom p-450 oxidases
what is bilirubin conjugated with
glucuronic acid
what is bilitrubil catabolised to in the liver
sterocobilinogen (colourless)
what is bilirubin oxidised to
stercobilin (coloured)
where is excess glucose diverted to
the pentose phosphate pathway
what does the pentose phosphate pathway do
makes NADPH
