Biochemistry - Cancer Flashcards
What are the forms of cancer cells?
Carcinoma
Sarcoma
Myeloma
Lymphoma
Leukmeia
Carcinoma
This is malignant new growth arising from epithelia, found in skinor lining of body orangs(80-90% of cancerS)
Sarcoma
These derive from connective and supportive mesenchymal tissues like bone or muscle cancer
Myeloma
These are cancer cell derived from the bone marrow
Lymphoma
These are solid tumours of the lymphatic systmes
Leukemia
This is production of abnormal white blood cells from the bone marrow
What features make normal cells non-cancerous?
Anchorage dependent growth
Densit-dependent growth
Metastasis
This is the dissemination of neoplastic cells to nearby or distant secondary sites where they proliferate to form an extravascular mass of tmor cells
What does density depencen refer to?
When a monolayer of EC form singular layer, they produe no more
How is metastasis facilitated?
Upregulation of Matric Metalloproteinases for reformation of the ECM and detachment from OG location
How may cancer detach from cells?
Downregulation of proteins required for it like E-cadherin
Anoiis
This is apoptotic induction in cells after they lose attachment to ECM
What do cancner cells have the capacity for?
Allow uncontrolled cell division by dysregulation of cell cycle checkpoint, growth factor secretion to promote cell proliferation
Reduced growth factor reliance
Hayflick Limit
This says that human cells will only replicate and divide 4-60 times before it cannot divide anymore
Why is cancer immortal?
Telomerase expression