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Unit 2 > Biochemistry > Flashcards

Biochemistry Flashcards

1
Q

What is the pKa of Asp? (Aspartic Acid)

A

pKa=4.0

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2
Q

What is the pKa of Glu? (Glutamic Acid)

A

pKa-4.0

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3
Q

What is the pKa of Lys? (Lysine)

A

pKa=10.0

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4
Q

What is the pKa of Arg? (Arginine)

A

pKa=12.0

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5
Q

What is the pKa of His? (Histidine)

A

pKa=6.5

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6
Q

What is the pKa of the N-terminus?

A

pKa=8.0

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7
Q

What is the pKa of the C-terminus?

A

pKa=4.0

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8
Q

What is the pKa of Cys? (Cystine)

A

pKa=8.5

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9
Q

What does a high pka mean?

What does a low pka mean?

A

High pKa means it binds H+ tightly.

Low pKa means it binds H+ weakly.

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10
Q

What is pKa?

A

The pKa of a group is the pH at which 50% of the molecules are ionized and 50% are non-ionized. Below the pKa, the group takes up H+ from solution, above pKa it releases H+ into solution.

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11
Q

What is the disease congenital erythropoietic porphyria and what are the symptoms?

A

Specific disease for heme synthesis, chronic conditions. Symptoms include anemia, photosensitive skin, hair growth over whole body-werewolf legend?

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12
Q

What enzyme is affected by congenital erythropoietic porphyria and which two substrates accumulate as a result? (Step 4)

A

Enzyme: uroporphyrinogen III co-synthase
Substrates: uroporphyrinogen I and coporphyrinogen I

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13
Q

What enzyme is affected by protoporphyria? (Last step)

A

Enzyme: ferrochelatase

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14
Q

What enzyme is affected by Acute Intermittent Porphyria and which two substrates accumulate as a result? (In the liver)

A

Enzyme: porphobilinogen (PBG) deaminase
Substrates: porphobilinogen (PBG) and ALA

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15
Q

What enzyme is affected by Porphyria Cutanea Tarda?

A

Enzyme: uroporphyrinogen decarboxylase
Substrate: uroporphyrinogen I

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16
Q

How do the enzymes proteases work?

A

Break a peptide bond by the addition of water across the bond

17
Q

What do HIV proteases do in the viral life cycle?

A

Cleave the poly-protein (that is translated by host RNA Pol) into its respective proteins-this process is essential for maturation of the virion

18
Q

How do HIV protease inhibitors work?

A

Binds to the hydrophobic active site of protein

Unit 2 (6 decks)

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