Biochemistry

Question 1

Iron absorbed by?

Answer 1

Enterpcytes in proximal duodenum

Question 2

Diatary iron (Fe+3) reduced to ferrous (Fe+2) by?

Answer 2

Ferrireductase enzyme

Question 3

The transfer of (Fe+2) from surface of enterocytes into their interior is performed by?

Answer 3

DMT-1

Question 4

(Fe+2) is oxidized again to (Fe+3) by?

Answer 4

Hephaestin (Ferroxidase) then combines with apoferritin to form ferritin

Question 5

The transport protein responsiple for release iron from intestinal cell to blood stream is?

Answer 5

Ferroportin

Question 6

What is the storage form of iron in cells and it contains 23% of iron?

Answer 6

Ferritin

Question 7

If the rate of eryhtropoiesis is increase due to hemorrhage, what will happen to iron absorption?

Answer 7

Increase

Question 8

What is the hormone that stimulate RBCs prodcution?

Answer 8

Erythropoietin

Question 9

What is the hormone produced in hepatocytes and controls the delivery of iron to blood plasma?

Answer 9

Hepcidin

Question 10

Gastric HCL helps iron absorption by?

Answer 10

Formation of soluble ferrous chelates

Question 11

What are the sites that ferritin can be present in?

Answer 11

Intestinal mucosal cells, liver, kidney, spleen and marrow

Question 12

Normally, there is a ….. amount of ferritin in human plasma

Answer 12

Little

Question 13

What is the plasma protein that transports iron as (Fe+3)?

Answer 13

Transferrin

Question 14

What is the blood test represnts the capacity of transferrin to bind protien?

Answer 14

Total iron binding capacity (TIBC)