Biochemical Alterations Induced by Oral Contraceptives

Question 1

Which are the Biochemical Alterations Induced by Oral Contraceptives?

Answer 1

● Enhanced blood coagulation (Estrogen-induced, decrese Antithromin III)
● Increased levels of plasma proteins (Estrogen-induced, ↑ thyroid h, cortisol, & Vitamin D binding globulins)
● Alterations in carbohydrate metabolism (Progestins ↑ insulin release)
● Alterations in blood lipids

Question 2

What are the characteristics of Alterations in blood lipids?

Answer 2

● Estrogens – favorable profile, except increase in triglycerides (bad!)
● C-19 1st generationprogestins–badprofile
● 2nd generation progestins – favorable profile b/c
they decrease free testosterone levels (testosterone normally ↑’s LDL and ↓’s HDL)