Biochem role Flashcards
Vit A / retinol
Proliferation and differentiation of ep cells
Chondritin sulphate synth
Increase no of GH receptors
Steroic hormone synth
Antioxidant
Visual func
Vit D / calciferol
Abs of Ca2+ and PO43+ from the intestine and kidney
Bones:
Newly formed= mineralization increase
Pre existing bones= demineralization
Vit E / tocopherol
H donor
Free radicals (ROS, RNS, RCS)
Antioxidant
B3 / nicotinic acid
Cofactor!
NAD+—> NADH+H+
NADP+ —> NADPH+H+
NADPH+H+ —> NADP+
B5 / pantothenic acid
Transamination
PALP
AST, ALP
PALP
decarboxylation
PALP
Heme synth
PALP
B7 / biotin
Pyr + CO2 —> OAc
BIOTIN
AcACoA + CO2 —> malonyl-CoA
BIOTIN
Propionyl-CoA + CO2 —> methylmalonyl-CoA
BIOTIN
B9 / folic acid
Purine synth
FH4
dUMP —> dRMP
FH4
Homocys—> methionine
FH4
Trp—> 5-OH-trp—> serotonin
FH4–> FH2
Tyr—> dioxy phenylalanine DOPA —> dopamine
FH4–> FH2
B6 / pyridoxine
HSCoA in different reactions
B12 / cobalamine
CH3 cobalamine
DA cobalamine
Intermolecular rearrangement
Propionyl-CoA —> methylmalonyl-CoA—> succinyl—CoA
DA-cobalamine
Methyl gr donator
Homocys—> methionine
CH3 cobalamine
Vit C / ascorbic acid
Reducing agent
Hydroxylation
Tyr—> 5-OH-tyr—> DOPA
Hydrogen donator
Folic acid—> FH2 —> FH4
Antioxidant effect
H2O2 —> 2H2O
B1 / thiamine
Oxidative carboxylation
Pyr—> OAc
TPP
Alpha Leto glut—> succinyl-CoA
TPP
ribose-5-p —> fructose-6-p
TTP
B2 / Riboflavin
H transport
Aerobe: FADH2 —> H2O2 + O2 (FAD out) —> H2O2
Xhantosine oxidase, monoamino oxidase
0 ATP
Anaerobe: Resp chain—> ox phosphorylation
H2O + 2ATP
Succinate dehydrogenase
FA-CoA DH
Vit K / phylloquinone
Gamma carboxylation of glu
Blood clotting
Prethrombin —> prothrombin glu—> gamma carboxy glu
Calcification of bones
K-cycle
