Biochem Mock Exam 1 Flashcards
What is produced in the first step of glycolysis?
Glucose 6-phosphate
Other options include fructose 6-phosphate, pyruvate, glucose, and acetyl CoA.
What is produced in the last step of glycolysis?
Pyruvate
Which two compounds become elevated in the blood when muscle cells operate anaerobically?
Pyruvate and lactate
Other options include glucose and oxygen, NAD+ and CO2, urea and pyruvate.
What effect does inhibition of pyruvate dehydrogenase phosphatase have on pyruvate dehydrogenase complex?
It will inhibit the dehydrogenase by keeping it phosphorylated
Other options include activating or inhibiting the dehydrogenase or phosphorylase.
What blood marker indicates a pyruvate dehydrogenase deficiency?
Pyruvate
Other markers include glucose, ketone bodies, lactate, and all of these are markers for PDC deficiency.
What is one way to treat individuals with PDC deficiency?
Biotin supplements
Other options include high carbohydrate diet, glucose pills, drugs that stimulate pyruvate dehydrogenase kinase, and high fat/protein diets.
Why are erythrocytes more sensitive to glycolytic defects than other tissues?
Erythrocytes rely exclusively on glycolysis for energy because they have no mitochondria
Other options include fragility of cells, lack of glycogen storage, low oxygen supply, and higher energy consumption.
