Biochem EX2 - Enzymes

Question 1

Enzyme needed for CoA synthesis

Answer 1

Pantothenate (B5)

Question 2

Inhibits glycolysis

Answer 2

Citrate

Question 3

Endothelial enzyme that binds to Apo CII

Answer 3

Lipoprotein lipase

Question 4

Anaplerotic enzyme of the citric acid cycle

Answer 4

Pyruvate carboxylase

Question 5

Inhibits phospholipase A2

Answer 5

Lipocortin

Question 6

Inhibits purine, pyrimidine synthesis & salvage pathway

Answer 6

PRPP synthetase

Question 7

Inhibits acetylcholinesterase

Answer 7

Physostigmine

Question 8

Thymidylate synthase

Answer 8

5-flurouracil

Question 9

Inhibits tetrahydrofolate

Answer 9

Methotrexate

Question 10

Reverses citrate synthase

Answer 10

Citrate lyase

Question 11

Catalyzes only substrate level phosphorylation in the citric acid cycle

Answer 11

Syccinyl CoA synthetase

Question 12

Starting Material for: Sphingolipid synthesis

Answer 12

Serine

Question 13

Starting Material for: Niacin

Answer 13

Hydroxyproline

Question 14

Committed Step for Purine synthesis

Answer 14

5’-phosphoribosylamine

Question 15

Committed Step for Cholesterol synthesis

Answer 15

HMG CoA reductase

Question 16

Rate Limiting Step for Cholesterol synthesis

Answer 16

HMG CoA reductase

Question 17

Rate Limiting Step for Pentose Phosphate Pathway

Answer 17

Glucose-6-Phosphate Dehydrogenase

Question 18

Enzyme Required by: Propionyl CoA Carboxylase

Answer 18

Biotin (B7)

Question 19

Enzyme Required by: Acetyl CoA Carboxylase

Answer 19

Biotin (B7)

Question 20

Enzyme Required by: Methylmalonyl CoA Mutase

Answer 20

Methylcobalamin (B12)

Question 21

Enzyme Required by: Transaminases

Answer 21

Pyridoxal Phosphate (B6)

Question 22

Enzyme Required by pathway: Cholesterol Synthesis

Answer 22

Acetyl CoA

Question 23

Enzyme Required by pathway: Fatty Acid Synthesis

Answer 23

Acetyl CoA

Question 24

Enzyme Required by pathway: Histone trans-acetylation

Answer 24

Acetyl CoA

Question 25

Enzyme Required by pathway: TCA Cycle

Answer 25

Acetyl CoA

Question 26

Apoprotein: A-1 is associated with?

Answer 26

HDL

Question 27

Apoprotein: ABCA1 is associated with?

Answer 27

HDL

Question 28

Apoprotein: Apoprotein(a) is associated with?

Answer 28

LDL

Question 29

Apoprotein: Apo CII is associated with?

Answer 29

Lipoprotein lipase

Question 30

Apoprotein: Apo M is associated with?

Answer 30

HDL (carrying sphingosine-P)

Question 31

Disease: Lesch-Nyhan Condition: Hyperuricemia Which enzyme is deficient?

Answer 31

HGPRT

Question 32

Disease: Condition: High Orotic Acid Which enzyme is deficient?

Answer 32

UMP Synthase

Question 33

Disease: Megaloblastic anemia Condition: Which enzyme is deficient?

Answer 33

Methylcobalamin (B12)

Question 34

Disease: Tay Sachs Condition: Sphingolipidosis Which enzyme is deficient?

Answer 34

Hexosaminidase A

Question 35

Disease: Metachromatic leucodystrophy Condition: Which enzyme is deficient?

Answer 35

Arylsulfatase

Question 36

Disease: Condition: Encephalophathy, renal tumors Which enzyme is deficient?

Answer 36

Fumarase

Question 37

Disease: Condition: Eye Disorders Which enzyme is deficient?

Answer 37

DNA polymerase gamma

Question 38

Disease: Hypercholesterolemia Condition: Which enzyme is deficient?

Answer 38

Ubiquinone

Question 39

Disease: Von Gierke Condition: Carbohydrate storage disease Which enzyme is deficient?

Answer 39

Glucose-6-phosphatase

Question 40

Disease: Pompe Condition: Muscle weakness (cardiomyopathy, diaphragm breathing disorder) Which enzyme is deficient?

Answer 40

Lysosomal alpha-1,4 alpha-1,6 glucosidase

Question 41

Disease: Refsum Condition: Which enzyme is deficient?

Answer 41

Phytanate alpha-hydroxylase

Question 42

Disease: Epilepsy Condition: Which enzyme is deficient?

Answer 42

GABA

Question 43

Disease: Condition: Substantia nigra damage Which enzyme is deficient?

Answer 43

dopamine