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Biochem Med Term 1 > Biochem Drugs - Pre Unified > Flashcards

Biochem Drugs - Pre Unified Flashcards

0
Q

List Anti-HIV Drugs

TAD
the tadpole got you into this mess in the first place

A

TAD

Tenofovir - DNA nucleotide
Azidothymidine (AZT) - RNA nucleoside
Didanosine - RNA nucleoside

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1
Q

List Diuretics

MAD

A

MAD (amides)

Methazolamide
Acetazolamide
Dichlorphenamide

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2
Q

List Varicella Zoster & Herpes Simplex Drugs

A

Acyclovir:

Analogue of deoxyguanosine

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3
Q

List Anti-Cancer Drugs

ACE AdD 5a

A

Ace AdD 5a

Arabinosides: araA araC
             Adenosine Arabinoside
             Cytosine Arabinoside
Camptothecin
Etoposide

Actinomycin D
Decitabine
5-azacytidine

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4
Q

List Transcription Inhibiting Antibiotics

Run After Clubbing

A

Run After Clubbing

Rifamycin (rifampin)
Actinomycin D
Ciprofloxacin

Drug class = coumarin (listed in notes-not sure)

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5
Q

List Translation Inhibiting Antibiotics

Sip Tea & Eat Cake

A

Sip Tea & Eat Cake

Streptomycin
Tetracycline
Erythromycin
Chloramphenicol

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6
Q

Acetazolamide

A

Diuretic

Carbonic anhydrase inhibitor
Increases NaHCO3 excretion

Other examples: methazolamide & dichlorphenamide

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7
Q

Methazolamide

A

Diuretic

Carbonic anhydrase inhibitor
Increases NaHCO3 excretion

Other examples: acetazolamide & dichlorphenamide

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8
Q

Dichlorphenamide

A

Diuretic

Carbonic anhydrase inhibitor
Increases NaHCO3 excretions

Other examples: methazolamide & acetazolamide

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9
Q

Azidothymidine (AZT)

A

Anti HIV

Nucleoside analogue of deoxythymidine

  • viral “reverse transcriptase” inhibitor
  • causes premature DNA synthesis termination

3’OH?????

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10
Q

Didanosine

A

Anti HIV

Nucleoside analogue of deoxyadenosine
-viral “reverse transcriptase” inhibitor

3’OH???

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11
Q

Tenofovir

A

Anti HIV

Analogue of deoxyadenosine monophosphate (nucleotide)
-viral “reverse transcriptase” inhibitor

3’OH???planar molecule

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12
Q

Acyclovir

A

Anti Varicella Zoster & Herpes Simplex

Analogue of deoxyguanosine
SPECIFICITY: phosphorylated by VIRAL kinase (not eukaryotic)
-causes DNA chain termination

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13
Q

Cytosine Arabinoside (araC)

A

Anti Cancer - Arabinosides

Analogue of cytosine deoxyribose
-inhibits DNA polymerase in rapidly dividing cells

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14
Q

Adenosine Arabinoside (araA)

A

Anti Cancer - Arabinosides

Analogue of deoxyadenosine
-inhibits DNA polymerase in rapidly dividing cells

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15
Q

Decitabine

A

Anti Cancer

Disrupts DNA methylation
-re-expresses ‘silenced’ genes which prevent uncontrolled cell division

16
Q

5-Azacytidine

A

Anti Cancer

Disrupts RNA methylation
-re-expresses ‘silenced’ genes which prevent uncontrolled cell division

17
Q

Etoposide

A

Anti Cancer

Inhibits Topoisomerase II leading to strand breaks and apoptosis

18
Q

Camptothecin

A

Anti Cancer

Inhibits Topoisomerase I leading to strand breaks and apoptosis

19
Q

Actinomycin D

A

Anti Cancer & Antibiotic
->transcription inhibitor

Inhibits replication by binding DNA
-prevents opening of the helix

20
Q

Rifamycin

A

Transcription Inhibitor - Antibiotic

Derived from streptomyces
- inhibits INITIATION of transcription by binding RNA polymerase in prokaryotes

21
Q

Ciprofloxacin

A

Transcription Inhibitor - Antibiotic

Selectively inhibits DNA gyrase (prokaryotic Topoisomerase II)

An example of Quinolones (?fluroquinolones)

22
Q

Streptomycin

A

Translation Inhibitor - Antibiotic

Prevents binding of fMet-tRNAf to the P site of ribosomes
initiation inhibitor

23
Q

Tetracycline

A

Translation Inhibitor - Antibiotic

Prevents animoacyl-tRNAs binding in the A site
elongation inhibitor

24
Q

Erythomycin

A

Translation Inhibitor - Antibiotic

Blocks translocation by binding the 50S subunit of prokaryotes

25
Q

Cholamphenicol

A

Translation Inhibitor - Antibiotic

Interferes with peptidyl transferase activity of the 50S ribosome, preventing peptide bond formation

26
Q

Quinolones and Coumarins

additional slide by Jen

A

The quinolones are a family of synthetic broad-spectrum antibacterial.

Quinolones exert their antibacterial effect by preventing bacterial DNA from unwinding and duplicating. The majority of quinolones in clinical use belong to the subset fluoroquinolones, which have a fluorine atom attached to the central ring system, typically at the 6-position or C-7 position.

DNA gyrase is all you need to know!

Biochem Med Term 1 (1 decks)

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