BIO2: Blood Brain Barrier Flashcards
What are neurones + astrocytes separated by?
Marrow clefts
What does brain ECF interact with?
Solute concentration in the ECF flunctuate with neuronal activity.
What does changes in ECF composition affect?
Neuronal behaviour
How does brain control ECF composition?
- CSF made by the choroid plexus
- BBB protects ECF from flunctuations in blood composition + limits entry into the ECF
- Glial cells condition the ECF
Describe CSF function
- Fills ventricles + forms thin layer around brain + spinal cord in the subarachnoid space
- CSF volume = 150 mls with 500mls made each day (turnover 3x daily)
- CSF secretion pushes existing CSF into subarachnoid space
- Acts as cushion or shock-absorber
- Provides appropriate local environment for neurones + glia
- Exchange medium between ECF + systemic blood
- Removes waste products
- Interface between brain + peripheral endocrine function
What order does the CSF flow from the brain to the spinal cord?
Where are CSF ventricles derived from?
Describe CSF circulation
How is CSF formed + secreted?
Describe mechanism of CSF secretion
What are the sites of CSF absorption?
How is CSF absorbed?
Describe diagnostic use of CSF
Describe clinical use of CSF
In the BBB, capillary endothelium cells of brain capillaries have tight junctions.
Why?
Outline the factors which regulate passage across BBB
What is the function of glucose transport + what is the the specific type of glucose transported?
Name amino acids which are readily transported
Name amino acids virtually transported
What cell contains metabolic barriers?
Why can’t dopamine be used to treat parkinson’s?
What can be used instead?
What are the BBB disorders?
What brain regions lack BBB?
Which brain region directly releases hormones into circulation + is not affected by BBB?
What are the sites of physical blockage in CSF circulation?
