BIO2: Blood Brain Barrier Flashcards
1
Q
What are neurones + astrocytes separated by?
A
Marrow clefts
2
Q
What does brain ECF interact with?
A
3
Q
Solute concentration in the ECF flunctuate with neuronal activity.
What does changes in ECF composition affect?
A
Neuronal behaviour
4
Q
How does brain control ECF composition?
A
- CSF made by the choroid plexus
- BBB protects ECF from flunctuations in blood composition + limits entry into the ECF
- Glial cells condition the ECF
5
Q
Describe CSF function
A
- Fills ventricles + forms thin layer around brain + spinal cord in the subarachnoid space
- CSF volume = 150 mls with 500mls made each day (turnover 3x daily)
- CSF secretion pushes existing CSF into subarachnoid space
- Acts as cushion or shock-absorber
- Provides appropriate local environment for neurones + glia
- Exchange medium between ECF + systemic blood
- Removes waste products
- Interface between brain + peripheral endocrine function
6
Q
What order does the CSF flow from the brain to the spinal cord?
A
7
Q
Where are CSF ventricles derived from?
A
8
Q
Describe CSF circulation
A
9
Q
How is CSF formed + secreted?
A
10
Q
Describe mechanism of CSF secretion
A
11
Q
What are the sites of CSF absorption?
A
12
Q
How is CSF absorbed?
A
13
Q
Describe diagnostic use of CSF
A
14
Q
Describe clinical use of CSF
A
15
Q
In the BBB, capillary endothelium cells of brain capillaries have tight junctions.
Why?
A
23
Q
What brain regions lack BBB?
A
