BIO1 - The physical basis of living systems Flashcards

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1
Q

*Why is our atmosphere important to life on earth?

A
  • Oxygen: respiration
  • Protect from radiation
  • Greenhouse gas effect, maintaining suitable temperature
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2
Q

*What are requirements for life as we know it?

A

1) Liquid water
2) An energy source
3) Temperatures compatible with biomolecules

Extra that may have helped for life on earth to develop:
1) Magnetic field and a dense atmosphere to protect from radiation
2) Large gas planets in our solar system to protect us from comets, asteroids etc.
3) a large moon

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3
Q

*What are the basic characteristics of living systems?

A

Life on earth is characterized by:
1) a peculiar out of equilibrium state (If an equilibrium state is one in which nothing seems to be happening, i.e., “equilibrium is death,” then a key distinction of all living systems is that they operate out of thermodynamic equilibrium, which requires that
they constantly burn energy, obtained from photosynthesis or metabolism, to stay alive.)

2) evolution
3) cellular organization.

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4
Q

*Why are viruses often not considered alive?

A
  • Lack of cellular structure. Instead they consist of genetic material surrounded by a protein coat.
  • No evolutionary process
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5
Q

*What features of our solar system/planet are particularly favourable for life?

A
  • Distance from the Sun => Goldilocks zone => liquid water, right temperatures for water to exist in its liquid state => essential for various biological processes.
  • Atmosphere composition (oxygen)
  • Magnetic field
  • Ozone layer
  • Stable orbit
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6
Q

*How can we remotely find signs of life on exoplanets?

A
  • Spectroscopy of exoplanets atmospheres. James Webb space telescope can look for evidence of life through measuring the gas composition of exoplanet atmospheres.
    Looking for out of equilibrium compositions, such as the simultaneous presence of methane and oxygen.
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7
Q

*What are examples of how living organisms can generate large scale geological structures?

A

Coral reefs, massive underwater structures formed by the accumulation of calcium carbonate exoskeletons secreted by coral polyps over time

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8
Q

*What is osmosis?

A

Osmosis is a major physical force that life has to deal with.
Osmosis is the movement of solvent molecules (usually water) across a selectively permeable membrane from an area of lower solute concentration to an area of higher solute concentration. The goal of osmosis is to equalize the concentration of solute on both sides of the membrane, but the solvent (water) moves to achieve this equilibrium

Osmosis in very high salt concentrations for instance the death sea. A living organism in the death sea; The water will try to leave the organism to dilute the death sea.

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9
Q

*How do organisms adapt to osmotic stress?

A

Organisms adapt to osmotic stress by regulating internal ion concentrations, producing compatible solutes, and adjusting cell membrane permeability. They may also employ water retention mechanisms and structural adaptations to minimize water loss. These strategies help maintain cellular homeostasis and prevent damage from fluctuations in external osmolarity.

by accumulating or releasing solutes, thereby attenuating water fluxes. Those solutes include inorganic ions (often K+), and organic molecules denoted “osmolytes”

Living cells often fight osmotic pressure by accumulating high
concentrations of soluble small molecules inside the cell, such as such as
polyols (glycerol, arabitol, mannitol, and glucosylglycerol), low-molecular-
weight nonionic carbohydrates (sucrose, trehalose, and glucose), free amino
acids and their derivatives (proline, glutamate, glycine, γ-aminobutyrate,
taurine, and β-alanine), etc.

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10
Q

*What is the role of ATP?

A

ATP stores and carries energy within cells. It consists of a molecule of adenosine linked to three phosphate groups. The high energy bonds between these phosphate groups can be broken, releasing energy that cells can use for variuos cellular activities

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11
Q

*What forms of energy does life use and how is energy stored in live cells?

A

The different forms of energy life can use:
1) Light (photosynthesis, not at the origin of life)
2) Energy rich inorganic compounds (chemolithotrophy). for example pyrite - FeS2
3) Energy-rich organic compounds (chemoorganotrophy)
4) potentially gradients in chemical species and temperature in the environment
(postulated for early organisms)

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12
Q

*What is an argument for the RNA-world hypothesis of the origin of life?

A

RNA can both store information AND has catalytic activity.
RNA plays a key role in all forms of life (mRNA, tRNA, ribosome)

This hypothesis is the most widely accepted theory about the origin of life.
The RNA-world hypothesis proposes that before DNA or proteins existed, RNA molecules served as both the genetic material and catalysts for early life forms. This hypothesis suggests that RNA played a fundamental role in the origin of life by storing genetic information and catalyzing chemical reactions, thus bridging the gap between simple molecules and the complex biological systems we see today

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13
Q

*Which basic properties of living systems are constrained by physical laws? (Hvilke grundlæggende egenskaber ved levende systemer er begrænset af fysiske love)?

A

1) Gravitation force affects: the body size of land and marine animals as well as the height of trees. F scales with length^3.
2) Diffusion of substances or heat affects the size of living cells, as diffusion t scales with length^2. Cells must maintain a size that allows for efficient exchange of substances and heat across their membranes, which imposes limits on their size.
3) Limited available energy supply/density affect the size and metabolic activity of organisms
4) Fluid transport through capillarity or pressure driven flow affects the design and functioning of biological structures, such as blood vessels, respiratory systems, and vascular plants.

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14
Q

*Why can marine animals grow larger than land animals?

A

The buoyancy (opdrift) of water enables ocean animals to grow to greater sizes than land animals, which need legs sturdy (solide) enough to support them

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15
Q

*Why are dissipative structures relevant for understanding life?

A

Dissipative structures are self organising structures that are maintained through the
dissipation of energy (entropy increase)

Dissipative structures are crucial for understanding life because they explain how living systems, unlike inanimate objects, actively maintain order and complexity far from thermodynamic equilibrium. Living organisms continuously dissipate energy, producing entropy in their surroundings while organizing and adapting to their environment. This concept helps elucidate the dynamic, self-organizing, and non-equilibrium nature of life, emphasizing the emergence of complexity, information processing, and adaptability in biological systems

Living things are always changing, but they manage to stay stable and organized. Dissipative structures show how systems can stay stable even when they’re constantly changing.

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16
Q

*How do diffusion and the diffusion coefficient scale with key properties of a particle/molecular (size, temperature, viscosity)?

A

Larger particle => Lower diffusion coefficient and slower diffusion
Higher Temperature=> Higher diffusion coefficient and faster diffusion
Higher viscocity => Lower diffusion coefficient and slower diffusion

17
Q

*How can diffusion lead to pattern formation?

A

Diffusion can lead to pattern formation if the system consists of reaction with unequal diffusion coefficients, then stable patterns and oscillations can emerge, as first proposed by Alan Turing.

  • Alan Turing, reaction-diffusion theory. Normally diffusion will lead to an equilibriating effect, leading to a decrease in conc. Gradients over time. However, if a reaction occur so the system contains molecules of different Dc then stable patterns and oscillations can emerge. These patterns can guide processes such as cell division and large scale pattern formation
18
Q
  • What is the Reynolds number? What is laminar flow? How does it scale with pressure,length and diameter of the vessel?
A

Reynolds number is the inertial to viscous forces. It is a dimensionless quantity used in fluid dynamics to characterize the flow of fluids, such as liquids or gases. lower values indicating laminar flow and higher values indicating turbulent flow.
Re<10: Laminar flow

Re=uL/mu=rhou*L/mu
Flow in living systems is often governed by low Reynolds numbers – laminar flow.

19
Q

*What kind of transport processes play a role in biology

A

transport processes (matter, energy, information) are key for life

Matter (stof) transport; (electro)-diffusion, capillary flow, pressure-driven flow.

Energy transport; ATP, protons, sodium ions

Information transport; diffusion, molecular motors, action potential

20
Q

*Give examples for biological properties governed by universal scaling laws.

A

Metabolic Rate: Metabolic rate scales approximately as the three-fourths power of body mass, known as Kleiber’s Law.

GENEREL: Y=Y0*m_{animal}^b

  • Metabolic rate B from Kleibers law: : B=B0*m_{animal}^0.75

Heart Rate: Heart rate scales inversely with body size, with smaller animals having higher heart rates relative to their body mass.

Lifespan: Lifespan scales with body size, with smaller animals generally having shorter lifespans compared to larger animals.

Vascular System: Blood vessel diameter scales with body mass to ensure efficient nutrient and oxygen delivery, while branching patterns follow fractal-like scaling relationships.

Movement and Locomotion: Limb proportions and muscle size scale with body size to maintain similar locomotor performance across species

21
Q

*How do biological magnetoreception and temperature sensing work?

A
  • Magnetoreception is a sense which allows an organism to detect the Earth’s magnetic field and in this way navigate. For instance ocean animals in the dark and birds navigating to the right location.
  • Two theories: 1) animals have tiny magnetite which is tiny magnetic recptors sentitive enough to capture the small variations in magnetic field. 2) Animals produce a protein in their eyes called cryptochrome allowing them to see magnetic fields.
  • We sense temperature in our environment through specialized nerve cells that project into the outer layers of the skin

Biological magnetoreception:

Ability of organisms to detect and orient themselves based on Earth’s magnetic field.
Mechanisms not fully understood; hypotheses propose use of specialized cells containing magnetite or cryptochromes.
Allows animals like birds, fish, and some mammals to navigate during migration or find their way.
Temperature sensing in organisms:

Involves specialized proteins called thermoreceptors.
Thermoreceptors detect changes in temperature and transmit signals to the nervous system.
Example: transient receptor potential (TRP) ion channels activated by temperature changes.
Found in various tissues, including nerve endings in the skin, enabling organisms to respond to temperature fluctuations for thermoregulation.

22
Q

-*What is chemotaxis?

A

Chemotaxis is the movement of cells or organisms in response to chemical gradients in their environment. It involves the detection of chemical cues (called chemoattractants or chemorepellents) and the directional movement of cells toward or away from the source of the chemical signal. Chemotaxis plays a crucial role in various biological processes, including the movement of immune cells toward sites of infection, the migration of sperm toward the egg during fertilization, and the navigation of bacteria toward nutrients or away from harmful substances.
This movement can be either toward (positive chemotaxis) or away from (negative chemotaxis) the source of a specific chemical signal.

23
Q

*Is there a universally accepted definition of life?

A

No, It is not straightforward to define life and no general agreement has been reached. NASA: Life is a self-sustaining chemical system capable of Darwinian evolution.

24
Q

What is anabolism and catabolism?

A

Anabolism: building complex molecules, use energy)
Catabolism (break down complex molecules, release energy)

Life is an interplay between anabolism and catabolism.

Anabolism builds and maintains the structures and molecules necessary for life, while catabolism provides the energy needed for cellular processes and the maintenance of cellular function. This interplay ensures that living organisms can grow, repair, and reproduce, maintaining the complex balance required for life to continue

25
Q

*How can energy be stored in living systems?

A

1) Gradient of ions (salt ions, protons)
2) Long-lived energy rich molecules (fat, starch)
3) Short-lived energy rich-molecules (AT,NADH)

26
Q

*What is most energy efficient - living system or artificial systems?

A

Muscles are not very efficient, but the brain is still several orders of magnitude more energy efficient than the best computers.

27
Q

What is the habitable zone around a star, mostly defined by the possible presence of liquid water called?

A

The “goldilocks” zone - Planet Earth is placed here.

28
Q

*Why is water important for life? What properties make it so special?

A

1) very polar and can form stron interactions. It is a good solvent for many polar substances.

Others could have worked (maybe) ; ammonia, hydrogen sulfide, hydrocarbons…

29
Q

How to calculate osmotic pressure?

A

The formula for calculating osmotic pressure is given by Van’t Hoff’s equation:
Pressure of ideal gas : p=(n/V)RT
Osmotic pressure for ideal solution:
PI=cRT
Osmotic pressure is the pressure exerted by a solvent when it passes through a semipermeable membrane to equalize the concentration of solute on both sides. The magnitude of osmotic pressure depends on the concentration difference across the membrane.

30
Q

How has life shaped our planet?

A

1) Oxygen rise in atmosphere
2) Inorganic deposits
(coral reefs, chalk cliffs),
carbon recycling through plate tectonics
3) Deposits of organic carbon (petrol, coal)
4) Albedo changes through variations in plant cover

31
Q

What does the Miller experiment in 1950 show?

A

that the molecules essential for life (amino acids) can be formed through processes that do not involve living organisms (reduction on H2, CH4, NH3)), known as abiotic processes.

32
Q

What is Jurins law?

A

Jurins law describes the rise of water against the effect of gravity in thin capillaries with hydrophilic surface. The equilibrium height of the water column depends inversely on the radius of the
capillary.

33
Q

How much of it are we producing? Be able to perform simple stoichiometric calculations of energy conversion (ATP)?

A