Bio Flashcards
Rosalind Franklin
Did work prior to Crick and Watson on DNA
Contributed to Crick and Watson’s discovery
Chargaff’s Rules
Concentrations of the four nucleotide bases differ among different species
Concentrations of adenine and thymine are always about the same, and cytosine and guanine are always about the same
DNA bases
Nitrogen-containing bases Adenine (A) Thymine (T) Cytosine (C) Guanine (G)
Double helix
Double strand of nucleotides that forms a spiral staircase shape
RNA bases
Nitrogen-containing bases Adenine (A) Uracil (U) Cytosine (C) Guanine (G)
Base pairing
DNA: A > T C > G RNA: A > U C > G
Hydrogen bonds
Type of bonds that occur between complementary bases and holds the nucleotides together
Deoxyribose
Sugar in DNA nucleotides
Ribose
Sugar in RNA nucleotides
DNA Replication
Process in which DNA is copied
Enzyme breaks hydrogen bonds of nucleotides
Another enzyme pairs new complementary nucleotides with parent
Two daughter molecules form, each with one new strand
mRNA (Messenger)
Copies the genetic instructions from DNA in the nucleus, and carries them to the cytoplasm
rRNA (ribosomal)
Helps form ribosomes, where proteins are assembled.
tRNA (transfer)
Brings amino acids to ribosomes where they are joined together to form proteins
Made of anti codons, so it can carry the correct amino acids the ribosome
Central dogma of molecular biology
DNA - RNA - Protein
Transcription
DNA > RNA DNA transfers info to mRNA by making an mRNA strand complementary to DNA Initiation Elongation Termination
Transcription - Initiation
Enzyme RNA polymerase binds to region of gene called the promoter
Unwinds DNA so enzyme can read it and make mRNA with complementary bases
Transcription - Elongation
Addition of nucleotides to strand of mRNA
Transcription - Termination
mRNA strand detaches from the DNA.
RNA Polymerase
Enzyme that binds to promoter in DNA so it can make a new mRNA strand
Promoter
Region of gene where the RNA polymerase binds to do initiation
Codon
Group of three nitrogen bases in nucleic acids that make up a code for a start, an amino acid, or a stop
Stop codons
UAA
UAG
UGA
Start codons
AUG
Genetic code
Encodes instructions for amino acid sequence
Universal- all organisms have same code
Unambiguous- each codon is for just one amino acid
Redundant- most amino acids are coded for by multiple codons