Bio Flashcards
-giga
10^9
Females
XX
Males
XY
Sex chromosomes?
Of the 23 pairs of chromosomes in the human cell - 1 is referred to as sex chromosomes
Y chromosome?
Much smaller than X and contains fewer genes
Y gene contains genes needed to initiate male sexual development
Sperm and egg
Sperm (of its 23 chromosomes) - 1 is either X or Y
Ovum - always contains X chromosome
At fertilisation?
Sperm cell determines the sex of the resulting zygote
Thus it’s 50:50 ; ratio of males to females is 1:1
Asexual reproduction
Parent plant produces a runner and new offspring develop along the length of the runner - divide by mitosis and differentiate into all cell types (genetically identical)
Genetic variation
Reduces frequency of recessive inherited conditions
Why are bacteria produced by binary fission (passing one loop of chromosomal DNA to each cell) not always genetically identical?
MUTATION MAY DEVELOP WHEN DNA COPIED (change in order of bases of DNA)
Cells in this plant leaf?
Divide by mitosis to produce tiny plantlets ; they will eventually drop to the ground and grow into new plants - genetically identical
Which type of human cell has no nucleus and thus no chromosomes?
MATURE red blood cells
Alleles?
Dominant (capital letter)
Recessive (small letter)
Genotype?
Alleles we have that control a characteristic
Genotype?
Two alleles for each gene (1 from each parent) - genotype can be written as two letters with each letter representing one allele of the gene
Phenotype?
Genes determine our phenotype but this can also be determined by environment
Homozygous?
Two alleles of a gene that are the same
Heterozygous?
Two different alleles of that gene
If dominant allele present?
Allele always determines the phenotype
Monohybrid cross
Cross between two individuals of a species where the impact of only a single gene is considered as a monohybrid cross
When 50% is result of punnets square?
1:1
Inheritance?
Genes and their alleles play a big role in determining our characteristics as genetic conditions (determined by alleles) can be passed down from one generation to the next
For recessive conditions?
Heterozygous = carrier
Homozygous recessive = sufferer
Expected probabilities of punnet squares not always seen?
Larger the sample size - more significant the expected probability
Height (continuous variation)
Example of a characteristic that is controlled by the action on more than one gene
If there is a mutation in the non-functional enzyme?
Phenotype is affected
Certain mutations
Very small effect on phenotype
Most mutations
No effect on phenotype - large sections of DNA on chromosomes do not code for proteins and these are unlikely to affect the phenotype
Silent mutations occur within a gene
Mutation changes base of DNA but not amino acids
Triplet code still codes for the amino acid
Mutation is silent because no effect on phenotyoe
Genetic engineering?
Copy of a gene from one organism and inserting that into DNA of another organism to create a genetically modified organism - TRANSGENIC
How does genetic engineering work?
Gene of interest cut from DNA of an organism using a restriction enzyme (breaks down phosphodiester bonds)
Restrictions enzymes cut DNA in a staggered way leaving short sections at the end of each gene - sticky ends
Bacterial plastic cut open using same restriction enzyme (same sticky ends that are
complementary to those on ends of gene)
Useful gene and plasmid DNA mixed and inserted into plasmid ; h bonds form between bases in sticky ends of plasmid
DNA Ligase used to join plasmid DNA and the useful gene together ; joins end nucleotides to end nucleotides of the plasmid
Plasmid description after?
Recombinant ; altered and has DNA from more than 1 source
Recombinant plasmid
Placed in bacteria and acts a vector in carrying that gene in the bacterial cell
Genetic engineering of plants?
Plant cells do not have plasmids ; bacteria are commonly used to create GM plants
How is plant cell gm different?
Recombinant ti plasmid created and is then inserted into a bacteria (tumefaciens) to create a transgenic bacterial cell ; the bacteria infects the plant cells when grown together and thus carries the useful gene into the plant genome (able to now produce the protein coded for by the gene)
Gm plants?
Significant yield of food crops - feed the increasing human population (pest/disease/herbicide resistance)
Benefits and risk of using Genetic engineering?
GM bacteria can produce hormone insulin which is used to treat diabetes
Can grow clotting factors for inherited diseases
Few side effects because protein from bacteria are human proteins
Long term consequences of GMO are unknown - a lot of scepticism
More medicine to be produced
GMO positive?
Vaccines - helps provide safer and cheaper vaccines for deadly diseases
Gene therapy negatives?
If not accurate then can cause cancer ; gene is inserted too close to a cancer causing gene
Risk of stem cell treatment?
Cancer developing
Rejection by the immune system because transplanted cells are foreign
Use of embryonic stem cells?
Controversial
Treating diabetes by replacing insulin secreting cells
Replacing neurones
Etc
Induced pluripotent stem cells?
No rejection
Less controversial than embryonic stem cells
Testing it on cell cultures before being used in a patient
Totipotent vs pluripotent?
Totipotent can differentiate to become the placenta but pluripotent cannot
Domesticated animals!
Animals that humans have tamed
Selective breeding?
Choose animals with desirable outcomes and use them for breeding - offspring also shows these characteristics
Selective breeding?
Animals with desirable characteristics are identified and bred - happens in a cycle over and over ; desirable characteristic starts to increase in the population
Disadvantages of selective breeding?
Reduces gene pool/variation ; result of inbreeding which increases likelihood of genetic conditions occurring
Why does inbreeding cause genetic diseases?
Alleles are often recessive ; increased chance of animals being homozygous recessive and thus de looong the condition
Other concerns?
Ethically speaking whether welfare of animals is affected - characteristic may not be desirable for the animal rather than humans
Inbreeding?
Reduces ability to cope with environmental stresses/adapt to new diseases etc
Species?
Fertile offspring
Population
All of the organisms of one species found in an area
Natural selection
Mutations have caused genetic variation in populations ; individuals will have different characteristics
Selective advantage?
Organisms with the advantageous alleles are better suited to their environment ; survival of the fittest - over many generations thus becomes more common
What else can cause variation?
Environment can alter the phenotype
Functional enzyme in stomach
Optimum ph = 2
Functional enzyme in small intestine
Optimum ph = 8
Carbohydrase?
Insoluble carbohydrates to soluble glucose
Lipid breakdown
3 fatty acids + 1 glycerol
Digestive enzymes
Extracellular
Inside cells
Intracellular (respiration/photosynthesis)
Energy for respiration used for?
Protein synthesis
Active transport
Cell division
Muscle contraction
Prokaryote aerobic respiration
In cytoplasm
During exercise?
May break down glycogen stores into glucose for respiration
Anaerobic respiration
Cytoplasm
Neurone
Nerves are made of bundles of the axons of neurones
CNS
Made up of the brain and spinal cord (nerves running through the vertebrae) ; nerves from receptors in the sense organs bring impulses to the spinal cord which sends them to the brain for processing (sends back an impulse via spinal cord to nerves)
Spine?
CNS CONTAINS SPINAL CORD NOT SPINE
Where are receptors found?
In sense organs (not CNS)
Neurone?
Nerve cell - transmit electrical impulses (single nucleus and extensions of cytoplasm allow electrical impulses to travel through them)
Sensory neurones
Connect receptors (detect stimuli) with CNS
Relay neurones
Connect sensory to motor neurones? And allow communication to and from brain
Motor neurone?
Connect central nervous system to efffectors - produce a response (muscles and glands)
Sensory neuron
Cell body in middle
Motor
Cell body at the end
Relay
Thin axon
Axon
Electrical impulse travels down
Myelin sheath
Protects the axon and makes impulse travel faster - dendrites allow connection to other neurones
Synapse
Small gap between two neurones ; allow neurones to transmit electrical impulses to each other - allow many neurones to connect with each other at once (made between dendrites)
How do impulses cross synapse?
Causes chemical to be released - neurotransmitter diffuses from axon to neurone on other side ; binds to receptor which allows the impulse to be regenerated - travels down axon of other neurones etc
Reflex arc
Protect the body from harm - bypass the brain
Reflex arc chain of events
Stimulus -> sensory neurone -> relay neurone -> spinal cord -> motor neurone -> effector
Bronchi and bronchioles
Both contain cartilage to ensure the airway remains open
Air entering the body
Contains more oxygen
Less CO2
Less water vapour
Contains pollen, dust, viruses
Normal exhalation
Passive (when active muscles on abdominal wall will also contract)
Inhale
Intercostal muscle contract and pull up and out
Diaphragm flattens (contracts)
Where is co2 transported
Blood plamsa