BIO 1140 - Cell Transport Across Plasma Membrane (Pt. 2) Flashcards

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1
Q

How are the Electrical Charges Inside and Out the Cell balanced?

A

Outside the cell, the charges of Na+ ions are balanced by Cl- ions.

Inside the cell, the charges of K+ ions are balanced by negative charges of organic molecules.

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2
Q

What creates a Voltage Difference?

A

Small excesses of positive or negative charge on the two sides of the plasma membrane create a voltage difference.

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3
Q

What is Membrane Potential?

A

This voltage difference across the membrane is called the membrane potential.

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4
Q

What is Resting Membrane Potential?

A

For a cell at rest, the exchange of anions and cations across the membrane is steady
- Resting membrane potential in animal cells varies between –20 to –200 mV.

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5
Q

What is the Role of Ion Channels?

A

Ion channels create membrane potential
- Ion channels create openings for the passive movement of inorganic ions

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6
Q

What Channels are responsible for the Resting Membrane Potential?

A

K+ leak channels are responsible for the resting membrane potential
- At rest, plasma membrane is mostly permeable to K+ (moving out of the cell)
- K+ is the main positive ion inside the cell

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7
Q

What other Channel contributes to the Resting Membrane Potential?

A

The Na+-K+ pumps also contribute to the resting potential
- establish the K+ gradient
- pumps 3 Na+ ions out of the cell for every 2 K+ ions in

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8
Q

What do Ion Channels facilitate?

A

Ion channels facilitate the passage of select inorganic ions.
- Most channels are narrow and highly selective
- Most channels in the cell are ion channels

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9
Q

What are the Two Characteristics of Ion Channels?

A

Two characteristics distinguish Ion channels from pores :
- Ion selectivity
- Fluctuates between open/closure conformations (not continuously open)

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10
Q

What are the different types of Gated Ion Channels?

A

A specific stimulus triggers gated-ion channels to switch between a closed and an open state by a change in their conformation.

  1. Ligand Gated
  2. Voltage Gated
  3. Mechanically Gated
  4. Always open (leak channels)
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11
Q

What are Voltage Gated Ion Channels?

A

Voltage-gated ion channels are controlled by changes in the voltage across the membrane

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12
Q

What are Ligand Gated Ion Channels?

A

Ligand-gated ion channels are controlled by the binding of a molecule
- Stimulus molecule binds to receptor site
- polar substance can diffuse across membrane

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13
Q

What are Mechanically Gated ion Channels?

A

Mechanically-gated ion channels are controlled by a physical stimuli
- physical stimuli include light, sound waves, pressure, stretch, touch and vibration

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14
Q

What are ion Channels responsible for?

A

Ion channels are responsible for electric signal generation and transmission in neurons

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15
Q

What are Neurons and Electric Signals?

A

A neuron (a nerve cell) consists of a cell body, axon and denrites.
- An electric signal consists of changes in the membrane potential across the neuron’s plasma membrane.

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16
Q

What are the different Components to a Neuron?

A
  1. Cell body: contains nucleus and cell’s organelles
  2. Dendrites: receive information from other neurons or sensory cells
  3. Axon: carry information from cell body to target cells via axon terminals
  4. Axon Terminals: branching of axon into fine nerve endings
17
Q

How are Activities of Neurons recorded?

A

Activities of neurons are recorded as changes in membrane potential
- Electrodes are used to record electrical events in a cell
- The resting potential of a neuron is usually between –60to –70 millivolts (mV)
- The minus sign indicates that the inside of the cell is electrically negative compared with the outside

18
Q

What is an Action Potential?

A

A rapid change in membrane potential is an action potential
- Neuron stimulation shifts the membrane potential to a less negative value (toward zero, depolarization)
- Action potentials are sudden, transient, large changes in membrane potential

19
Q

What does Depolarization cause?

A

Depolarization causes voltage-gated Na+ channels in the membrane to open transiently.

20
Q

What do Action Potentials result from?

A

Action potentials result from rapid changes in voltage gated Na+ and K+ channels

21
Q

What is Repolarization?

A

The depolarized axonal membrane returns to its resting potential by the opening of voltage-gated K+ channels (repolarization).

22
Q

What are the Behaviours of Action Potentials?

A
  • Action potentials travel along axons
  • Action potentials jump along myelinated axons
  • Action potential propagates in one direction
23
Q

Where do Neurons connect to Target Cells?

A

Neurons connect to their target cells at synapses
- The signal is transmitted to the target cells at specialized junctions known as synapses
- Presynaptic and the postsynaptic cells are separated from each other by synaptic cleft

24
Q

How many Synapses form between Cell Body and Spinal Cord?

A

Thousands of synapses form on the cell body and dendrites of a motor neuron in the spinal cord

25
Q

What is an Electrical Signal converted into at Nerve Terminals?

A

The electrical signal is converted into a chemical signal (neurotransmitter)
- Neurotransmitters receptors are ligand-gated ion channels.

26
Q

What is Chemical Signal converted into?

A

A chemical signal is converted into an electrical signal at a synapse

27
Q

What type of ion Channels are responsible for Muscle Contraction?

A

Ligand (neurotransmitter)-gated ion channels are responsible for muscle contraction

  • The acetylcholine receptor in the muscle cell membrane opens when acetylcholine binds to it
28
Q

What is Acetylcholine?

A

Acetylcholine is the ligand responsible for Na+ ion channel activity in neuromuscular junction.
- Acetylcholine is a neurotransmitter

29
Q

What does the Nature of Ligand Gated ion Channels determine?

A

The nature of the ligand-gated ion channel which binds the neurotransmitter determines the excitatory or inhibitory effect on the postsynaptic cell.
- Neurotransmitters can either excite or inhibit a postsynaptic cell.

30
Q

What do Psychoactive Drugs target?

A

Psychoactive drugs target ligand (neurotransmitter)-gated ion channels
- Alcohol mimics inhibitory neurotransmitters
- Barbiturate, Valium, Ambien and Restoril are sedative and tranquilizers.
- Agonists mimic the ligand. Alcohol is the agonist of GABA.
- Antagonists compete with the ligand for the ligand binding site
- Heroinblocks excitatory neurotransmitters
- Cocaine blocks dopamine re-uptakefrom the synapse
- Nicotinemimicsexcitatory neurotransmitters

31
Q

What type of ion Channels allow us to hear?

A

Mechanically-gated ion channels in auditory hair cells allow us to hear