Bio 105 Exam 2 Flashcards

1
Q

Which of the following statements concerning
development of antibiotic resistance is FALSE?

A. Resistant cells grow more efficiently and quickly than susceptible cells and will therefore always increase in a population once resistance is formed
B. Resistant cells grow less efficiently and more slowly than susceptible cells and will therefore decrease in a
population if antibiotic use is stopped
C. Resistant cells are normally the minority of a bacterial population
D. New resistance genes can be gained through transformation,
transduction, or conjugation
E. Resistance often comes from resistance genes

A

Resistant cells grow more efficiently and quickly than susceptible cells and will therefore always increase in a population once resistance is formed

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2
Q

Nipah virus outbreaks occurred after pig farms were set up near populations of wild bats. Bats ate fruit from trees and dropped virus-infected fruits down into pig pens. Pigs then became sick
and transmitted the virus to human care-givers. This fact shows that Nipah virus outbreaks are heavily dependent on which of the following factors that affect disease emergence?

A. Poverty and social
inequality
B. technology
C. Economic
development and
land use
D. Climate and
weather

A

Economic
development and
land use

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3
Q

One way to prevent a global pandemic
of avian flu would be to

A. Provide most people with drugs
to stimulate fever
B. Treat any infected birds with
large doses of antibiotics
C. Keep large doses of histamine
available to treat anyone who
shows signs of infection
D. Develop a vaccine against the
avian flu virus
E. Develop drugs that would
effectively block or stop
anaphylactic shock

A

Develop a vaccine against the
avian flu virus

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4
Q

Among the virulence factors produced by Staphylococcus aureus are antiphagocytic factors, superantigen, kinase, coagulase, hyaluronidase, and collagenase. WHICH of these factors contribute(s) to the ability of S. aureus to hide from or avoid the immune system?

A. Hyaluronidase and
collagenase
B. Superantigen
C. Coagulase and
kinase
D. Antiphagocytic
factors

A

Coagulase and
kinase AND Antiphagocytic
factors

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5
Q

Read the following examples and consider
which is NOT an example of an emerging
disease?

A. Lymes disease increasing in
the US as more and more
people are in contact with
deer and their ticks
B. Guinea worm infection since
cases are going down due to
increased water filtration and
education
C. The rise of antibiotic resistant
strains of tuberculosis
bacteria
D. New diseases such as
HIV/AIDS that is currently
causing a global pandemic

A

Guinea worm infection since
cases are going down due to
increased water filtration and
education

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6
Q

Common ways that antibiotics target
bacterial cells include

A. Inhibition of cell
wall synthesis
B. Inhibition of protein
synthesis
C. Inhibition of nucleic
acid synthesis
D. All of the above are
common antibiotic
targets

A

All of the above are
common antibiotic
targets

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7
Q

Once antibiotic resistance is gained in one bacterial cell, it can spread to others in a population rapidly WITHOUT cell division. Which of the following is a means by which this spread could occur?

A. Transformation
B. Conjugation
C. Mutation
D. A and B are correct

A

A and B are correct

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8
Q

Reasons that antibiotic resistance is on the rise today includes

A. Doctors prescribing
antibiotics for viral
infections (overuse of
antibiotics)
B. Livestock fed antibiotics to
prevent infections and
help animals grow
stronger and faster
C. People not taking all of
their antibiotics or not
taking them as prescribed
D. All of the above are
correct

A

All of the above are
correct

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9
Q

Which of the following is transmitted by contamination/exposure to mucous
membranes as the portal of entry?

A. Trichomonas via
sexual contact
B. Warts by contact
with a fomite
C. Malaria transmitted
by mosquito
D. Hepatitis C
transmitted by
blood transfusion

A

Trichomonas via
sexual contact

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10
Q

Vaccination increases the number of

A. Antigens circulating in
the bloodstream
B. Antibodies and
lymphocytes with
receptors that can bind
to the pathogen
C. Phagocytic cells that are
specific for a certain
pathogen
D. Different receptors that
stabilize a pathogen

A

Antibodies and
lymphocytes with
receptors that can bind
to the pathogen

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11
Q

How can penicillin inhibit cell wall formation and
cause death of bacteria but leave the eukaryotic
host cells unharmed?

A. Penicillin does destroy the cell
wall of eukaryotes and that’s
why there are side effects to
this antibiotic
B. Eukaryotes actively pump
penicillin out of the cell by
production of an efflux pump
C. Eukaryotes produce
penicillinase and penicillinase
prevents penicillin from
causing damage to their cell
wall
D. Eukaryotic animal cells do not
have a cell wall

A

Eukaryotic animal cells do not
have a cell wall

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12
Q

The body’s adaptive immune defenses
against infection include

A. Barriers such as skin and
mucous membranes
B. Lymphocytes such as B
and T cells
C. Defensive proteins such
as interferons produced
by virus-infected cells
D. Phagocytic cells
E. Several nonspecific
antibodies

A

Barriers such as skin and
mucous membranes, Defensive proteins such
as interferons produced
by virus-infected cells, Phagocytic cells

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13
Q

A unique feature of the flu of 1918 was seen in
all of it’s victims. What was the unique feature?

A. Heliotrope cyanosis—a
blue discoloration of
the face and neck due
to low oxygen levels
B. Very high fever
C. Death within 48 hours
D. Wheezing and coughing

A

Heliotrope cyanosis—a
blue discoloration of
the face and neck due
to low oxygen levels

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14
Q

Killer T cells have attacked and destroyed a cluster of bacterial invaders. Upon looking at the destroyed bacterial cells, what do you see in the membrane and cell walls as a result of the T cell attack?

A. Attached antibodies
B. Perforin holes
C. Histamine
D. High levels of
interferons and
histamine

A

Perforin holes

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15
Q

Flu virus H1N3 is named as such
because of

A. The specific type of HA
and NA receptor spikes
found on the surface of
the virus
B. The type of hosts it can
infect
C. The form taken by the
genome (whether DNA or
RNA is the nucleic acid)
D. The timing of the
outbreak (if it is in spring
or fall)

A

The specific type of HA
and NA receptor spikes
found on the surface of
the virus

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16
Q

Which of the following statements
about antibodies is FALSE?

A. Antibody molecules are Y-
shaped and have two antigen
binding sites
B. Antibody molecules may flag
or tag a virus, bacterium, or
toxin for phagocytosis
C. Antibodies are nonspecific
and may bind to more than
one type of antigen
D. Antibody molecules may
block viral attachment to host
cells and cause clumping of
viral particles

A

Antibodies are nonspecific
and may bind to more than
one type of antigen

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17
Q

In which of the following does the placental
route serve as a portal of entry for disease
transmission?

A. A toxoplasmosis parasite
crosses from the mother to
the fetus
B. A person is contaminated
with HIV virus from a blood
transfusion
C. The flu virus is introduced to
the body when a person rubs
their eye with contaminated
fingers and the virus is
washed into the nasal cavity
by way of tears
D. Fungi digest the outer layer of
skin

A

A toxoplasmosis parasite
crosses from the mother to
the fetus

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18
Q

Which of the following is an immediate
effect of histamine release?

A. Fever and pain
B. The secondary
immune response
C. Constriction of local
blood vessels and
increase in blood
pressure
D. Dilation of local blood
vessels to allow fluid
and immune cells to
rush to the area

A

Dilation of local blood
vessels to allow fluid
and immune cells to
rush to the area

19
Q

A patient comes into the hospital for lung nodules (precancerous lesions) and surgery to remove them. However, a day after the surgery, the patient develops a very high fever from a bacterial infection. This person has contracted a(n)

A. Urinary tract infection
from biofilm that
formed on a catheter
or tube
B. An infection caused
by malnutrition
C. A cardiac infection
D. A nosocomial
infection

A

A nosocomial
infection

20
Q

Which age group had the highest mortality
(death) rate in the flu outbreak of 1918?

A. Elderly people died at
a higher rate
B. Young children died
at a higher rate
C. Healthy people in the
range of 18-25 died at
a higher rate
D. All age groups
suffered and died
equally

A

Healthy people in the
range of 18-25 died at
a higher rate

21
Q

Type A flu can evolve through antigenic shift
while type B flu cannot. Why is it that only Type
A flu can undergo antigenic shift?

A. Type B flu infects birds,
pigs, and humans
B. Type A flu only infects
humans
C. Type A flu infects birds,
pigs, and humans
D. Cells infected with Type
A flu release interferons

A

Type A flu infects birds,
pigs, and humans

22
Q

A newborn that is accidentally given a drug
that destroys the thymus would most likely

A. Lack innate immunity
B. Be unable to
differentiate and
mature T cells
C. Have a reduced
number of B cells and
be unable to form
antibodies
D. Have a compromised
humoral response

A

Be unable to
differentiate and
mature T cells

23
Q

When the balance between host and microbe is tipped in favor of the microbe, results.

A. Attachment of the
phage
B. Infectious disease
C. Anaphylactic shock
D. Toxin production

A

Infectious disease

24
Q

Typhoid Mary unknowingly infected many people with Typhoid bacteria. What was the route of transmission when Mary cooked and spread the typhoid bacteria?

A. Fecal-oral route
B. Bacteria from feces
contaminated Mary’s
hands and she passed
the bacteria to others
when she cooked for
them
C. Waterborne route
D. Airborne route

A

Fecal-oral route - Bacteria from feces
contaminated Mary’s
hands and she passed
the bacteria to others
when she cooked for
them

25
Sneezing and/or coughing may be involved in transmission of pathogens. A. Fecal-oral B. waterborne C. Droplet or airborne D. Vector
Droplet or airborne
26
What type of immunity is associated with breast-feeding? A. Cell-mediated immunity B. Innate immunity C. Passive immunity D. Active immunity
Passive immunity
27
Which of the following is considered an example of mechanical vector transmission? A. House-fly transmission of E. coli B. Mosquito transmission of Plasmodium C. Tsetse fly transmission of Trypanosoma D. Sexual transmission of HIV virus E. Both B and C are correct 30
House-fly transmission of E. coli
28
Which of the following is FALSE regarding genetic mutations and antibiotic resistance in bacteria? A. Mutations are random and occur by chance alone B. Mutations are generated by bacteria and other organisms on purpose as a directed response to the presence of the antibiotic to ensure that they can survive C. Mutations could be deleterious, neutral, or advantageous with equal probability D. Mutations are generally the result of errors during DNA replication during cell division
Mutations are generated by bacteria and other organisms on purpose as a directed response to the presence of the antibiotic to ensure that they can survive
29
A woman is bitten by a lizard that happens to be carrying Salmonella and other bacteria in/on it’s mouth and saliva. The bite breaks the skin and almost immediately, becomes very red, warm, and swollen. What response is occurring? A. Inflammation B. Mobilization of red blood cells and oxygen C. Active immunity D. Anaphylactic shock
Inflammation
30
Viruses such as flu and HIV can accumulate slow, gradual changes in nucleic acid sequences over time. This is called A. Antigenic mixing B. Antigenic shift C. Antigenic drift D. Antigenic emergence
Antigenic drift
31
What is the causative agent of Typhoid fever? What are the signs and symptoms of Typhoid fever? Mortality rate?
Salmonella typhi is the causative agent of Typhoid. Weakness, fever,headache, diarrhea are all signs and symptoms and 1/10 died from the diseases
32
How is it possible for a cook to transmit the infection to new hosts and how could transmission be prevented?
The cook got feces and bacteria on her hands when she went to the restroom and because she didn’t wash her hands properly, the bacteria was transferred to the food she prepared.
33
Who is Mary Mallon and what is her background?
Mary is an Irish immigrant that was a healthy carrier of typhoid fever
34
What is a healthy carrier?
A healthy carrier is someone that is infected with a pathogen but is not sick and shows no symptoms.
35
How were Irish immigrants treated and why were immigrants thought to be the cause of disease?
They were treated poorly and as if they were stupid and the cause of disease. People believed miasmas concentrated where immigrants lived.
35
What about the conditions of New York in the late 1800’s made it prime for infectious disease?
The city was filthy and had thousands of immigrants coming through. It was very crowded and had no sewer system so the streets were filled with waste of both human and animal excrement.
36
How does one become a carrier of Typhoid fever? What happens with the immune system and why are there no symptoms of infection? Are carriers still contagious?
They are infected with the pathogen but their immune system reacts in a way to protect them and keep them healthy but still is unable to eliminate the pathogen. Yes, carriers are still contagious.
37
What is a quarantine island? What are most patients sick with on the island that Mary is sent to?
North Brother Island and Riverside hospital was an island that they sent sick people to. Most were sick with tuberculosis and other very contagious diseases, but Mary was healthy.
38
What percent of people who recover from Typhoid become carriers? Why is this a problem and how did the health department test and keep track of carriers who were cooks?
3% of people infected with Typhoid fever become carriers and this is a huge number in a city like New York City. The health department tried to keep track by requiring food handlers to carry a card and be subjected to regular testing.
39
What conditions of war allow a greater environment for disease transmission of pandemic proportions?
- years of strains shortages -crowding -Poor nuthtion -lack of sleep - Stress - poor med care -mass transit of people
40
The R0 of 2019-nCoV is estimated to be 2.2. What is R0 a measurement of, and what does a value of 2.2 indicate about this virus?
The R0 is a measure of the rate of transmission. If it is 2.2 it means that each infected person infects on average 2.2 others
41
Explain how large-scale genetic changes (antigenic shift and recombination) of coronaviruses might occur. Be sure to describe the steps in detail! You may include a drawing if you like.
If two viruses infect the same cell simultaneously, the genetic elements of the viruses can mix or recombine to form a new virus.
42
Initial infections were treated with antibiotics, which proved ineffective. Why do you think antibiotics are not effective treatments for SARS-CoV2?
Antibiotics were ineffective because they treat bacteria and the SARS CoV 2 is a virus.