Biliary, Exocrine & Hepatic Disorders (Day 2) Flashcards
Hepatitis: Inflammation of the Liver
Causes:
Viral (most common)
Alcohol
Medications
Chemicals
Autoimmune diseases
Metabolic problems
Widespread inflammation
Acute infection:
Lysis/necrosis of infected hepatocytes
Proliferation & enlargement of Kupffer cells
Cholestasis: Inflammation of peri-portal areas interrupt bile flow
Liver cells can regenerate
Systemic Side-effects
Rash
Angioedema
Arthritis
Fever, Malaise
Hepatitis A Virus (HAV)
RNA virus
Transmission: Fecal-oral route; Contaminated food or drinking water
Increased risk: Illicit drug users, MSM, travel to developing countries
Mild to acute liver failure; Not chronic
Incidence decreased with vaccination
Acute onset; Mild, flu-like symptoms
Frequently occurs in small outbreaks
Prevention: Hepatitis A Vaccine & Handwashing
Hepatitis B Virus (HBV)
DNA virus
Transmission: Perinatal, percutaneous, small cuts on mucosal surface, exposure to infectious blood, blood products, or other body fluids
Increased risk: MSM, contact with chronically infected, hemodialysis health care & public safety workers, IV drug users, blood product transfusion
Acute or chronic; 30% asymptomatic
Incidence decreased with vaccination
Prevention: HBV Vaccine (Recommended for all, routine for children)
3 IM Deltoid injections
0, 1 & 6 months
Hepatitis C (HCV)
RNA virus
Transmission: Percutaneous
Increased risk; IV drug use, high-risk sexual behavior, occupational exposure, perinatal exposure, blood transfusions before 1992
Acute HCV 80% asymptomatic
Highly persistent
Can lead to chronic liver damage
Prevention: Personal protection similar to HBV
No vaccine
Health Promotion
Hep A
Hepatitis A
Personal & environmental hygiene
HAV Vaccine
1-year of age
Adults at risk
Post-exposure prophylaxis:
HAV vaccine
Immune globulin (IG)
Special precautions for health care personnel
Health Promotion
Hep B
Hepatitis B
General measures
Vaccines
Recombivax HB
Engerix-B
3 IM injections
All children
At-risk adults
Post-exposure prophylaxis:
Vaccine
Hepatitis B immune globulin (HBIG)
Health Promotion
Hep C
Hepatitis C
No vaccine
General measures
Screen those born between 1945 -1965
No post-exposure prophylaxis
Baseline & follow-up testing
Pathophysiology
Hep
Acute infection
Many hepatocytes destroyed
Liver cells can regenerate normally after infection
Chronic infection
Can cause fibrosis
Progress to cirrhosis
Antigen-antibody complexes activate complement system
Many asymptomatic; Symptoms intermittent or ongoing
Anorexia
Malaise, fatigue, lethargy
Myalgia, arthralgia
Right upper quadrant tenderness
Pre-icteric Phase (1 - 21 days)Period of Maximal Infectivity for HAV
Acute phase
Maximal infectivity
Symptoms during incubation
Nausea, vomiting
RUQ tenderness
Reduced sense of smell
May find food repugnant
Distaste for cigarettes
Anorexia
Constipation
Diarrhea
Malaise
Headache
Low-grade fever
Arthralgia
Skin rashes
Icteric Phase (Jaundice & Pruritis)1 – 6 months
Not all patients will have jaundice (Anicteric Hepatitis)
Acute phase
Hepatomegaly
Lymphadenopathy
Splenomegaly
With jaundice, patient can also have
Dark urine
Light or clay-colored stools
Pruritus
Jaundice
Symptom
Alteration of bilirubin metabolism
Flow of bile into hepatic-biliary systems
Bilirubin approximately 3x normal
Hemolytic
Hepatocellular
Obstructive
Yellow sclera
Yellow-orange skin
Clay-colored feces
Tea-colored urine
Pruritis
Fatigue
Anorexia
Post-Icteric (Convalescence) Phase
Begins as jaundice disappears
Lasts weeks to months (Average 2 – 4 months)
Major problems
Malaise
Easy fatigability
Hepatomegaly persists
Splenomegaly subsides
Most patients recover completely with no complications
Most cases of acute HAV resolve
Some HBV & most HCV result in chronic hepatitis
Complications
Hep
Acute Liver Failure
Encephalopathy d/t livers inability to remove toxins – especially Ammonia
Potentially life-threatening spectrum of neurologic, psychiatric, & motor disturbances
GI bleeding
Fever with leukocytosis
Renal manifestations
Liver transplant usually the cure
Portal Hypertension
Liver Cancer
Chronic Hepatitis
Some HBV, most HCV
Chronic HBV more likely in infants & those < 5 YO
< 50% immunocompromised adults with HBV progress to chronic infection
Cirrhosis
Male sex
Alcohol use
Fatty liver disease
Excess iron in liver
Ascites; Accumulation of fluid in peritoneum d/t reduced protein in blood (reduces plasma oncotic pressure)
Hepatitis: Diagnostic Studies
Specific antigen / antibody for each type of hepatitis
Liver function tests
Viral genotype testing
Physical assessment findings
Liver biopsy
FibroScan
FibroSure (FibroTest)
Hepatitis: Collaborative Care
Overall goals:
Relief of discomfort
Return to normal activities
Return of normal liver function without complications
Expected outcomes:
Adequate nutritional intake
Increased activity tolerance
Able to “Teach back”
Follow-up care
Methods of transmission & prevention
HAV: Collaborative Care
No specific treatment
Most managed at home
Symptom management
Promethazine (Phenergan)
Ondansetron (Zofran)
Diphenhydramine (Benadryl)
Rest
Assess degree of jaundice
Follow-up for at least 1-year
HBV & HCV: Collaborative Care
Medications for HBV:
LT treatment with Nucleoside / Nucleotide analogs; Inhibit DNA replication & decrease viral load
Lamivudine (Epivir)
Adefovir (Hepsera)
Used in higher doses to treat HIV
Interferon; Anti-viral, anti-proliferative, immune-modulating
SQ injection
Side effects make adherence challenging
Use limited d/t better tolerated, more effective treatments
Medications for HCV:
Ledipasvir 90 mg / Sofosbuvir 400 mg (Harvoni)
1 tablet, once / day
Clinical studies of HARVONI demonstrated cure in 96 – 99% adults with HCV
Genotype1 & no prior treatment
12-weeks of therapy
Provider determines length of treatment
Nutritional Therapy
Hep
No special diet needed; Emphasis on well-balanced diet patient can tolerate
Adequate calories (2500 – 3000 / day) important during acute phase
Frequent small meals
Anorexia worse during day; Concentrate efforts to take in calories at breakfast
Fatty foods may need to be reduced to decrease nausea
Vitamins B-complex & K
IV glucose or enteral nutrition
Protein 75 – 100 g/day; Decreased with encephalopathy to prevent ammonia build-up
Restrict sodium / fluids with edema
Thiazide diuretics; Increase food sources with K+
Avoid alcohol