Biliary Disorders Flashcards
- Cholelithiasis - Cholecystitis
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Is the most common disorder of the biliary system
Stones in the gallbladder
Cholelithiasis
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Is inflammation of the gallbladder wall
Usually assoc w/cholelithiasis & occurs together but a person can have cholelithiasis w/o ___
May be present acutely or chronically
Cholecystitis
Gallbladder Disease
- Common health problem
Risk factors
> Female
Multiparity
Age older than 40 yrs
Estrogen therapy; oral contraceptive use
Sedentary lifestyle
Genetics/ethnicity
Obesity [causes inc secretion of cholesterol in bile]
Cholelithiasis
- Cause of gallstones unknown
- Develops when balance that keeps cholesterol, bile salts, & calcium in solution is altered, leading to precipitation
> i.e., d/t infection & disturbances in metabolism of cholesterol
- Bile secreted by liver is supersaturated w/cholesterol (lithogenic bile)
> Other components of bile that precipitate into stones are bile salts, bilirubin, calcium, & protein
Mixed cholesterol stones, which’re predominantly cholesterol, are the most common gallstones
- Stasis of bile > supersaturation & changes in composition of bile (biliary sludge)
- Immobility, pregnancy, & inflammatory or obstructive lesions of biliary system ↓ bile flow
- Stones may remain in GB or may migrate to cystic or CBD
- Cause pain as they pass through ducts
Cholecystitis
- Most commonly assoc w/obstruction from gallstones or biliary sludge
___ cholecystitis [in the absence of obstruction]
> Older adults & critically ill
> Prolonged immobility, fasting, prolonged parenteral nutrition, diabetes
> Bacteria or chemical irritants
> Adhesions, neoplasms, anesthesia, opioids
acalculous (cholecystitis)
Cholecystitis - Inflammation
- Confined to mucous lining or entire wall
- GB is edematous and hyperemic & may be distended w/bile or pus
- Cystic duct may become occluded
- Scarring & fibrosis after attack
Clinical Manifestations
- Vary from severe to none at all
- Pain more severe when stone moving or obstructing
> Steady, excruciating
> Tachycardia, diaphoresis, prostration
> May be referred to shoulder/scapula
> Residual tenderness in RUQ
> Occurs 3-6 hrs after high-fat meal or when pt lies down
When total obstruction occurs:
> Dark amber urine
Clay-colored stools
Pruritus
Intolerance to fatty foods
Bleeding tendencies
Steatorrhea
- If the CBD is obstructed, no bilirubin will reach the SI to be converted to urobilinogen
- Thus bilirubin will be excreted by the kidneys instead, causing dark amber to brown urine
- In addition to pain
> Indigestion
Fever, chills
Jaundice
Pain, tenderness RUQ
- Referred to right shoulder, scapula
> N/V
Restlessness
Diaphoresis
- Inflammation
> Leukocytosis, fever - Physical exam findings
> RUQ or epigastrium tenderness
> Abd rigidity
Chronic cholecystitis Manifestations
> Fat intolerance
Dyspepsia
Heartburn
Flatulence
Cholelithiasis & Cholecystitis - Complications
- Gangrenous cholecystitis
- Subphrenic abscess
- Pancreatitis
- Cholangitis [inflammation of biliary ducts]
- Biliary cirrhosis
- Fistulas
- GB rupture > (bile) peritonitis
- Choledocholithiasis (stone in the CBD > obstruction)
In older pts & those w/diabetes, gangrenous cholecystitis & bile peritonitis are the most common complications of cholecystitis
Diagnostic Studies
- US (to diagnose gallstones; useful for pts w/jaundice & those allergic to contrast medium)
- ERCP
> Visualize GB, cystic duct, common hepatic duct, & CBD
> Bile sent for culture
- Percutaneous transhepatic cholangiography
> Is the insertion of a needle directly into the GB duct, followed by injection of contrast materials
> Generally done >US indicates a bile duct blockage
Laboratory tests
↑ WBC count (d/t inflammation)
↑ serum bilirubin (direct/indirect) & urinary bilirubin [if an obstructive process present]
↑ liver enzymes (alkaline phosphatase, ALT, AST)
↑ serum amylase (if pancreatic involvement)
- Treatment dependent on stage of disease
- Oral dissolution therapy [to dissolve stones]
> Ursodeoxycholic acid (ursodiol) [Actigall]
> Chenodeoxycholic acid (chenodiol) - Gallstones aren’t usually treated w/rx’s, b/c high use & success of laparoscopic cholecystectomy
ERCP w/sphincterotomy (papillotomy)
- Visualization
- Dilation (balloon sphincteroplasty)
- Placement of stents; sphincterotomy
- Open sphincter of Oddi, if needed
- Endoscope passed to duodenum
- Stones removed w/basket or allowed to pass in stool
Endoscopic Sphincterotomy
- An endoscope is advanced through the mouth & stomach until its tip sits in the duodenum opposite the CBD
- After widening the duct mouth by incising the sphincter muscle, the physician advances a basket attachment into the duct & snags the stone
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This is an alternate treatment used when stones cannot be removed by endoscopic approaches
Extracorporeal shock-wave lithotripsy (ESWL)