Bile Acid Sequestrants

Question 1

Bile Acid Sequestrants Drugs

Answer 1

Chole- or Cole-
* Cholestyramine
* Colestipol
* Colesevelam

Question 2

Bile Acid Sequestrants Method of Action

Answer 2

Binds bile acids in the intestine, allows excretion in feces
instead of reabsorption

Question 3

Bile Acid Sequestrants Indication

Answer 3

• Hypercholesterolemia
  
  • High cholesterol
  • High LDLs
• Pruritis associated with partial biliary obstruction

Question 4

Bile Acid Sequestrants Adverse Drug Effects

Answer 4

Adverse Drug Effects:
* Direct GI irritation
* Nausea
* Constipation
* Vitamin A, D, E and K deficiencies
* Increased bleeding times

Drug-Drug Interactions:
* Malabsorption of fat- soluble vitamins
* Affect absorption of other oral drugs

Question 4

Bile Acid Sequestrants Caution/Absolute Contraindication

Answer 4

Contraindications:
* Absolute: Allergy
* Relative: Complete biliary obstruction; Abnormal intestinal function

Caution:
* pregnancy

Question 5

Bile Acid Sequestrants ADPIE 1

Answer 5

Assessment-
History:
* Allergy, pregnancy and lactation
* Impaired intestinal function/obstruction

Physical:
* Skin, GI system

Labs: cholesterol, lipid levels

Nursing Conclusions:
* Impaired comfort
* Constipation
* Injury risk
* Knowledge deficit

Question 6

Bile Acid Sequestrants ADPIE 2

Answer 6

Implementation:
* Powdered drugs must be mixed in liquid
* Tablets cannot be cut, chewed, or crushed
* Give the drug before meals
* Administer other oral meds 1 hr before or 4 to 6 hrs after bile acid
sequestrants
* Arranged for a bowel program as appropriate
* Comfort and safety measures for adverse effects
* Provide thorough patient teaching

Evaluation:
* Evaluate response to drug
* Evaluate the effectiveness of the teaching plan
* Evaluate the effectiveness of comfort and safety measures
* Evaluate the compliance with the regimen