Bile acid-binding resins

Question 1

Drugs

Answer 1

Cholestyramine
Colestipol
Colesevelam

Question 2

M.O.A

Answer 2

Exchange chloride ions for bile acid in the gut -> Bind to bile acids -> bile acid-resin complex is excreted -> prevens enterohepatic cycling -> Liver synthesize replacement bile acid from cholesterol.

Bind
NOT ABSORBED FROM GUT

Question 3

Adverse

Answer 3

Constipation
Fecal impact
Irritated perianal area
Skin rash

Question 4

Indications

Answer 4

Hypercholesterolemia - last chance
Diarrhea
Pruritus

Question 5

How are they administered?

Answer 5

Cholestyramine and colestipol
- Powder to mix with water or juice

Cholestyramine
- Chewable bar

Colesevelam
- Tablets

Question 6

Interactions

Answer 6

Cholestyramine and Colestipol - 2 hrs space
Digoxin
Thyroxin
Warfarin

Question 7

Ezetimibe (Ezetimibe - Glucoronide)

Answer 7

Moa - Inhibts absorption dietary cholestrol (Annexin-2 & Caveolin-1)

Indication - H.cholesterolemia (alone or w/statin)
Homozygos familial H.cholesterolemia(w/statin)

Adverse - Well tolerated - headache & Myalgia = rare