Big dude Flashcards
What are amyloids
Highly organized folded state of protein that can be formed from virtually any polypeptide. They are of considerable significance to human and animal health
Represent a common form of misfolded proteins that give rise to amyloid diseases
Why are amyloids highly stable
Main-chain stabilizing interactions
Side chain stabilizing interactions
How do cavities affect amyloids
Fibrils seek to optimize van der Waals contacts avoiding internal cavities
How does charge repulsion affect Amyloids
Electrostatic repulsion between and within charged ladders destabilize fibrils
How does steric clash affect amyloids
Steric clashes weaken the structure and delay fibril growht
Functional amyloids vs artificial amyloid vs pathological amyloid
Key difference between functional and pathological amyloids
Stability
Pathological amyloids are remarkable stable and resistant to degradation
What is a proteinopathy
Protein misfolding disease
