BG

Question 1

Fosamax

Answer 1

alendronate

Question 2

Bisnoto

Answer 2

Alendronate effervescent tab

strawberry flavor

Question 3

Actonel

Answer 3

Risedronate

Question 4

Atelvia

Answer 4

Risedronate delayed release

take after breakfast (enteric coated)

Question 5

Boniva

Answer 5

Ibandronate

Question 6

Reclast

Answer 6

Zoledronic acid
5 mg IV once per year
infuse over >15 min; fever

Question 7

Zometa

Answer 7

4 mg IV q3-4 weeks
for hyperCa, multiple myeloma, metastasis lesions
infuse over >15 min

Question 8

Aredia

Answer 8

Pamidronate
HyperCa associated with malignancy, osteolytic and Paget’s.
infuse over 2-24hrs to decr renal impair
30-90 mg IV q3-4 weeks
cause osteonecrosis of the jaw

Question 9

Prolia

Answer 9

Denosumab
for pt with high risk for fractures
60 mg SC every 6 month–osteoporosis
refrigerated

Question 10

Xgeva

Answer 10

Denosumab
120 mg SC monthly for cancer
prevention of skeletal related events in cancer pts with bone metastases solid tumor

Question 11

Miacalcin

Answer 11

calcitonin
For paget, hyperCa, post-meno osteoporosis
salmon allergy; refigerated
35 days RT
nasal, IM/SC

Question 12

Fortical

Answer 12

calcitonin
salmon allergy; refigerated
30 days RT

Question 13

Forteo

Answer 13

Teriparatide
MOA: recombi parathyroid hormone
20 mcg SQ daily ; discard the 28 doses (3mL pen) after 28 days
-refrigerated all times
SE: orthostatic hypotension, incr uric acid, incr Ca (monitor Dig toxicity)

Question 14

Evista

Answer 14

Raloxifene
SERMs, post menopausal
60 mg daily

Question 15

MOA of Denosumab

Answer 15

IgG2 monoclonal antibody; binds to RANK ligand –> prevent osteoclast formation
cause osteonecrosis of the jaw