beta oxidation

Question 1

what are the steps of b oxidation

Answer 1

activation of fatty acid to acyl coa

transport of acyl coa to mitochondria

b oxidation proper

Question 2

what are the steps of transport of acyl coa

Answer 2

1) transport of acyl to carnitine for formation of acyl carnitine by enzyme carnitine acyl transferase I
2) transport of acyl carnitine to inner mitochondrial matrix by translocase
3) transport of acyl group to coa by carnitine acyl transferase II
4) reformation of acyl coa in mitochondrial matrix and liberation of carnitine to cytosol by translocase

Question 3

what are the name of steps of b oxdn proper

Answer 3

oxdn by FAD
hydration
second oxidation by NAD
Ssplittin/ cleavage

Question 4

what is rxn of b oxdn proper

Answer 4

palmityl coa —-> trans enoyl coa

e; acyl coa dehydrogenase

transenoyl coa——> b hydroxy acyl coa (HMG COA)

e: enoyl coa hydratase

b hydroxy acyl coa —-> b keto acyl coa

e; b hydroxy acyl coa dehydrogenase

b keto acyl coa —–> acetyl coa(8) + acyl coa

e; acyl coa acetyl transferase

this cycle repeats 7 times

Question 5

regulation of b oxdn is ??

Answer 5

CAT I is regulated by malonyl COA

in well fed stage, insulin prodn occurs, malonyl coa increases, fatty acid oxdn decreases

in starvation, glucagon inc, malonyl coa decrease, fatty acid oxdn inc

Question 6

how many atps are formed acc to old n new calcn

Answer 6

old —
FADH- 7x 2= 14

NADH- 7x3=21

TCA CYCLE -12x8[no of acetyl coa] = 96

atp required in activation process : 2

net atp = 129

new—

7x1. 5= 10.5
7x2. 5= 17.5

10x8=80

atp in activation process:2

NET ATP = 108