Beta Lactams: Penicillins Flashcards

1
Q

What are the natural PCNs?

A

PCN G (IV), PCN VK (PO), Procaine PCN (IM), Benzathine PCN (IM)

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2
Q

What are the natural penicillins good for treating?

A

Treponema pallidum, some streptococci, and some enterococci

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3
Q

What are the natural PCNs poor at treating?

A

atypicals and almost everything else due to resistance

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4
Q

What are the antistaphylococcal PCNs (penicillinase-resistant)?

A

nafcillin (IV), Oxacillin (IV), and dicloxacillin (PO)

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5
Q

What are the antistaphylococcal PCNs good at treating?

A

MSSA and streptococci

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6
Q

What are the antistaphylococcal PCNs poor at treating?

A

gram - rods, enterococci, anaerobes, MRSA, and atypicals

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7
Q

What are the aminopenicillins (extended spectrum PCNs)?

A

Amoxicillin (PO), Ampicillin (PO, IV)

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8
Q

What are the aminopenicillins good at treating?

A

streptococci, enterococci, some gram - rods

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9
Q

What are the aminopenicillins poor at treating?

A

staph, anaerobes, and atypicals

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10
Q

What are the antipseudomonal PCNs (broad spectrum PCNs) ?

A

Piperacillin (IV) and Ticarcillin (IV)

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11
Q

What are the antipseudomonal PCNs good at treating?

A

many gram - rods, including pseudomonas. Also treats streptococci and enterococci

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12
Q

What are the antipseudomonal PCNs poor at treating?

A

staph, anaerobes, and atypicals

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13
Q

What are the 4 combination drugs in the beta-lactam/beta-lactamase inhibitor category?

A

amox/clav (PO), ampicillin/sulbactam (IV), pip/tazo (IV), tic/clav (IV)

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14
Q

What are the beta-lactamase inhibitors good at treating?

A

MSSA, strep, enterococci, anaerobes, enteric gram - rods

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15
Q

Which two drugs in the beta-lactamase inhibitor category cover Pseudomonas?

A

pip/tazo and tic/clav

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16
Q

What are the beta-lactamase inhibitors poor at treating?

A

MRSA, ESBL producing gram - rods

17
Q

What kind of half life do the natural PCNs, antistaphylococcal PCNs, and aminopenicillins have?

A

very short half life

18
Q

What is the DOC for syphilis?

A

natural PCNs

19
Q

Which category of Penicillins are eliminated via the liver and therefore require no renal adjustments?

A

antistaphylococcal PCNs

20
Q

Utility of amox?

A

URIs like pharyngitis and otitis media

21
Q

what is the DOC for susceptible enterococci?

A

AMP

22
Q

Which drug has good activity against Acinetobater, a highly drug-resistant GNR that causes nosocomial infections?

A

Sulbactam