Beta Lactam

Question 1

Father of chemotherapy

Answer 1

Paul Ehrlich

Question 2

What did Paul discovered

Answer 2

Salvarsan 606

Question 3

How to choose chemotherapeutic agent

Answer 3

1. ID of the organism
2. Safety of the drug
3. Site of infection
4. Patient medical Hx

Question 4

What are the classifications of antibiotics

Answer 4

1. Inhibitors of cell wall synthesis
2. Inhibitors of protein synthesis
3. Inhibitors of Nucleic acid synthesis
4. Cell membrane disruptor

Question 5

What are inhibitors of nucleic acid synthesis

Answer 5

Rifampicin, Quinolones, Sulfonamides

Question 6

What are the inhibitors of cell wall synthesis

Answer 6

Penicillins, Vancomycin, Cephalosporin

Question 7

What are the inhibitors of protein synthesis

Answer 7

Tetracyclines, Chloramphenicol, Lincosamides, Aminoglycosides, Macrolides

Question 8

What is the cell membrane disruptor

Answer 8

Amphotericin B

Question 9

drugs kill bacteria all through out

Answer 9

Bactericidal

Question 10

drugs arrest the growth & replication of bacteria, thus giving the body’s immune system a chance to destroy & remove the pathogens

Answer 10

Bacteriostat

Question 11

beta lactams are ____ in activity

Answer 11

Bactericidal

Question 12

What are the mechanisms for AMR

Answer 12

1. Production of inactivating enzymes
2. Changes in drug penetration
3. Changes in receptor structure
4. Alteration in metabolic pathways

Question 13

Where do lactmases break B-lactam

Answer 13

C-N

Question 14

What R group does B lactam ring has

Answer 14

Secondary amino group

Question 15

Lactamases hydrolyze B lactam ring to form ____

Answer 15

penicilloic aci