Beta Blockers

Question 1

Example of a Beta Blocker

Answer 1

Atenolol

Question 2

How do Beta Blockers work?

Answer 2

Beta1-adrenoreceptors are located mainly in the heart, whereas β2-adrenoreceptors are found mostly in smooth muscle of blood vessels and the airways. Via the β1-receptor, β-blockers reduce force of contraction and speed of conduction in the heart. This relieves myocardial ischaemia by reducing cardiac work and oxygen demand, and increasing myocardial perfusion. They improve prognosis in heart failure by ‘protecting’ the heart from the effects of chronic sympathetic stimulation. They slow the ventricular rate in atrial fibrillation mainly by prolonging the refractory period of the atrioventricular (AV) node. SVT often involves a self-perpetuating (‘re-entry’) circuit that takes in the AV node; β-blockers may break this and restore sinus rhythm. In hypertension, β-blockers lower blood pressure through a variety of means, one of which is by reducing renin secretion from the kidney, since this is mediated by β1-receptors.

Question 3

Indications of Beta Blockers

Answer 3

Ischaemic heart disease: as a first-line option to improve symptoms and prognosis associated with angina and acute coronary syndrome.

Chronic heart failure: as a first-line option to improve prognosis.

Atrial fibrillation: as a first-line option to reduce the ventricular rate and, in paroxysmal atrial fibrillation, to maintain sinus rhythm.

Supraventricular tachycardia (SVT): as a first-line option in patients without circulatory compromise to restore sinus rhythm.

Hypertension: although not generally indicated for initial therapy, they may be used when other medicines (e.g. calcium channel blockers, ACE inhibitors, thiazide diuretics) are insufficient or inappropriate.

Question 4

Contra-indications of Beta Blockers

Answer 4

In patients with asthma, β-blockers can cause life-threatening bronchospasm and should be avoided. This effect is mediated by blockade of β2-adrenoreceptors in the airways.

Beta-blockers are usually safe in chronic obstructive pulmonary disease, although it is prudent to choose a β-blocker that is relatively β1-selective (e.g. atenolol, bisoprolol, metoprolol), rather than non-selective (e.g. propranolol).

When used in heart failure, β-blockers should be started at a low dose and increased slowly, as they may initially impair cardiac function.

They should be avoided in patients with haemodynamic instability and are contraindicated in heart block. Beta-blockers generally require dosage reduction in significant hepatic failure.

Question 5

Side-effects of Beta Blockers

Answer 5

Commonly cause fatigue, cold extremities, headache and gastrointestinal disturbance (e.g. nausea). They can cause sleep disturbance and nightmares. They may cause impotence in men.

Question 6

Possible interactions of Beta Blockers

Answer 6

Beta-blockers must not be used with non-dihydropyridine calcium channel blockers (e.g. verapamil, diltiazem). This combination can cause heart failure, bradycardia, and even asystole.

Question 7

Elimination of Beta Blockers

Answer 7

Renal

Question 8

Patient information on Beta Blockers

Answer 8

Beta-blockers are usually prescribed orally as part of the patient’s regular medication.

Orally administered β-blockers should be taken at equal intervals (e.g. roughly the same time each day for once daily drugs such as bisoprolol);

Intravenous preparations (e.g. of metoprolol) are available for use when rapid effect is necessary. Intravenous preparations should be prescribed and administered only by those experienced in their use, and only in a closely monitored environment.

Warn patients with heart failure about the risk of initial deterioration in their symptoms, and advise them to seek medical attention if this occurs. Warn patients with obstructive airways disease to stop treatment and seek medical advice if they develop any breathing difficulty.