Beta Blockers Flashcards
BB block ….. which are found in the ……
Beta adrenoreceptors
Heart, lungs, bronchi, vessels, pancreas, liver
MOA of BB
Slow the heart and depress the myocardium
Which BB are more effective?
Where are B1 and B2 found?
Equally effective
B1 in heart
B2 in lungs
Intrinsic sympathomimetic activity is…
The BB ability to stimulate and block adrenergic receptors
ISAs cause …… and ……
Less bradycardia and less coldness of extremities
Examples of ISAs are….
ICE PACO
Pindolol
Acebutalol
Celiprolol
Oxprenolol
Which BB cause less nightmares and why
Water soluble because theyre less likely to cross the BBB
Celiprolol
Atenolol
Nadolol
Sotalol
Water CANS
Which BB have the least effect on beta (bronchial receptors) what does this mean?
Cardioselective
Less effect on airways hence better to give in well controlled asthmatics if no other alternative
Which BB are chosen in coexisting conditions e.g., MI, HF at a low dose
Cardioselective
By specialist and monitor closely
Examples of Cardioselective
MANBA
Metoprolol
Atenolol
Nebivolol
Bisoprolol
Acebutalol
Is sotalol a Cardioselective BB
No
Which BB are long acting. How freq are they given daily?
BANC
Bisoprolol
Atenolol
Nadalol
Celiprolol
Can BB be used in diabetics?
Yes but with caution (preferably cardioselective BB)
When can BB not be used in diabetics? Why?
In those with frequent episodes of hypoglycaemia because it masks its symptoms such as tachycardia
BB can cause …. in patients with or without diabetes
Hypo or hyperglycamia
Can BB be used in HF
Only stable HF it is CI in unstable HF
Propranolol indications
Migraine prophylaxis
Anxiety
Thyrotoxicosis
BB cautions
1st degree AV block
Diabetes
Respiratory problems- asthma, COPD
BB can reduce the effectiveness of …..
Epipens because they reduce the response to adrenaline (epinephrine )
which BB can be used in pregnancy
Labetolol
BB contraindications
Unstable HF
2nd and 3rd degree AV block
With verapamil - can cause heart block
BB can mask the symptoms of …..
Thyrotoxicosis and hypoglycaemia
Severe interaction of BB with….
Verapamil —> risk of hypotension bradycardia which can lead to heart block
SE of BB
alopecia
Dry eyes and rashes (reversible)
GI and visual disturbances
Sexual dysfunction
Fatigue
Thrombocytopenia
Dry eyes and rashes can be caused by… but is it reversible?
BB
Yes
Thrombocytopenia is a SE of…
BB
Which BB is associated with liver damage
Labetalol
