Benzos, barbs, ket, all those induction meds <3 Flashcards

Test 3

1
Q

Ketorolac IM/IV dose

A

30 mg

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2
Q

30 mg IM/IV Ketorolac is equal to what dose of meperidine?

A

100 mg of meperidine without the respiratory depression and CV effects

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3
Q

Onset of Ketorolac IM/IV

A

30 min - 1 hour

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4
Q

Peak effect of Ketorolac IM/IV

A

2-3 hrs

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5
Q

Dose to decrease liver toxicity for Acetaminophen

A

< 2,600 mg/day or <650 mg single dose

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6
Q

> 13 yo. Acetaminophen

A

1 gm/15 minutes

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7
Q

2-13 yo. Acetaminophen

A

15 mg/kg

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8
Q

Ketamine induction dose

A

1-2 mg/kg; 4-8 mg/kg IM

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9
Q

Ketamine LOC

A

30-60 seconds IV; 2-5 minutes IM

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10
Q

Ketamine return to consciousness

A

15 minutes

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11
Q

Ketamine full orientation

A

60-90 minutes (dose dependent)

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12
Q

Ketamine Subanesthetic doses

A

0.2-0.5 mg/kg IV

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13
Q

Ketamine onset

A

30 seconds

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14
Q

Ketamine duration

A

5-15 minutes (dose dependent)

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15
Q

Ketamine elim. 1/2 time

A

2-3 hours

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16
Q

When should you discard propofol?

A

6 hours

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17
Q

Propofol infusion syndrome dose

A

> 75 mcg/kg/min for >24 hours

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18
Q

Propofol induction dose

A

1.5-2.5 mg/kg IV

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19
Q

Propofol peds dose

A

MORE d/t higher Vd and fast clearance

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20
Q

Propofol elderly dose

A

DECREASES d/t lower Vd and slower clearance

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21
Q

Propofol sedation dose

A

25-100 mcg/kg/min

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22
Q

Propofol maintenance dose

A

100-300 mcg/kg/min

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23
Q

Propofol elimination 1/2 time

A

0.5-1.5 hrs

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24
Q

Propofol context sensitive 1/2 time

A

<3 hrs = 10 minutes
>3 hrs = 25 minutes
>8 hrs= 40 minutes

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25
For propofol's antiemetic and antipruritic effects
Can give small dose about 10 mg for both
26
Propofol onset
30 seconds
27
Thiopental shelf life
lasts only 6 days at room temp, 2 weeks in fridge
28
Thiopental pH
10.5 (alkaline=bacteriostasis)
29
Thiopental decreases CMRO by ...
55% (the best at this!)
30
Thiopental cerebral protection dose
39.5 mg/kg
31
Thiopental re-distribution 1/2 life
2-4 minutes
32
Thiopental elim 1/2 life
10-12 hours
33
Thiopental protein bound
85% protein bound (remember, only unbound drug is available to cross BBB)
34
Thiopental induction dose
3-5 mg/kg
35
Thiopental onset
30 seconds
36
Thiopental duration
5-10 minutes
37
Methohexital elimination 1/2 time
3.9 hours (because decreased lipid solubility compared to thiopental)
38
Methohexital induction dose
1-2 mg/kg IV
39
Methohexital sedation dose
0.2-0.4 mg/kg
40
Methohexital rectal dose (lol)
25 mg/kg
41
Methohexital onset
30 seconds (rectal < 5 mins)
42
Methohexital duration
5-10 minutes
43
Methohexital elimination
2-5 hours
44
Etomidate myoclonus can occur in:
50-80% who don't recieve premed of fentanyl or benzo
45
Etomidate decrease of CMRO2 by...
35-45% (thio is 55%)
46
Etomidate can cause adrenocortical suppression after a single dose. How long could you see these effects?
Approx. 30 minutes after a single dose, lasts 4-8 hours after dose. May last up to 48 hours.
47
Etomidate dose
0.3 mg/kg
48
Etomidate onset
14-45 seconds
49
Etomidate duration
3-12 minutes
50
Etomidate elimination
2-5 hours
51
Precedex decreases MAC by
> 90% (with halothane)
52
Precedex re-distributon 1/2 time
6-8 minutes
53
Precedex context sens 1/2 time after 1 HOUR
25 to 120 minutes
54
Precedex context sens 1/2 time after 6 HOURs
87 to 250 minutes
55
Precedex loading dose
0.5-1 mcg/kg over 10 minutes (do not bolus)
56
Precedex infusion
0.2-1.4 mcg/kg/hr (can go up to 2 for sedation in MRI)
57
Precedex intranasal peds
1-2 mcg/kg then an infusion until end of surgery
58
Precedex emergence delirium prophylaxis
0.5 mcg/kg after induction or just prior to emergence, follow with an infusion at normal rates
59
Midazolam apnea can occurs with...
Rapid injection of >0.15 mg/kg IV
60
Midazolam onset
0.9-5.6 minutes (wait to redose!)
61
Midazolam only ___ reaches circulation due to first-pass effect
50%
62
Midazolam elimination 1/2 time
1-4 hours
63
Midazolam peds pre-medication
0.3-0.5 mg/kg PO 30 minutes before
64
Midazolam sedation dose
1-2.5 mg IV
65
Midazolam induction
0.1-0.2 mg/kg IV Terri said she likes 10 mg
66
Diazepam decreases MAC up to __%
30%
67
Diazepam has minimal resp. depressant effects until ___ mg/kg IV
0.2 mg/kg IV
68
Desmethyldiazepam (metabolite of diazepam) has an elimination 1/2 life of:
48-96 hours
69
Diazepam elimination 1/2 life
21-37 hours
70
Cirrhosis can increase the elimination of diazepam up to __ times
5 times
71
Diazepam dosage PO (adult)
10-15 mg Terri likes 5 mg
72
Diazepam peak effect
55 minutes
73
Lorazepam dose
50 mcg/kg (up to 4 mg)
74
Lorazepam peak concentration
2-4 hours
75
Lorazepam's antegrade amnesia can last up to __ hours
6 hours
76
Lorazepam elimination 1/2 life
10-20 hours
77
Remimazolam distribution 1/2 life
0.5-2 minutes
78
Remimazolam context sens. 1/2 time
6 mins. after 2 hrs. 7 mins. after 8 hrs.
79
Dose of remimazolam
0.1, 0.15, 0.2 mg/kg (not sure if we need to know these)
80
Flumazenil dose
0.2 mg IV
81
Flumazenil onset
2 minutes
82
Flumazenil additional doses
0.1 mg IV (up to 1 mg) q 60 sec.
83
Flumazenil duration
30-60 minutes
84
Flumazenil decrease sedation dose
0.3-0.6 mg
85
Flumazenil abolish benzo effect
0.5-1 mg