Benzos Flashcards
1
Q
Benzos Prototype
A
Diazepam / Valium
2
Q
2-3 x potency of diazepam
A
midazolam / versed
3
Q
midazolam / versed effect time at site equilibratioin
A
0.9-5.6 minutes
4
Q
rapid redistribution and short duration
A
midazolam / versed
5
Q
midazolam / versed E1/2t
A
1 - 6.5 hours
6
Q
GABA binds to ________
A
the 2 beta sites
7
Q
benzos bind to the _______
A
- gamma site
- GABA-A
8
Q
GABA receptor has distinct binding sites for
A
GABA, Barbituates, Benzos, ETOH
9
Q
GABA receptors are found on the ___________.
A
Post-synaptic memebranes in the CNS
10
Q
Benzos have a built in ________ that prevents them form exceeding the _______________of GABA inhabition.
A
- Ceiling effect
- physiologic maximum
11
Q
Benzos effects and precautions in anesthesia
A
- Dose dependant decrease in ventilation
- Hypoxemia and hypoventilation enhanced in presence of opioid
- Contraindicated in pregnancy
- Decreased SVR at induction doses
- very cardiac stable
12
Q
Benzos do not directly cause ____________. They may do so if the pateint is ___________ or if their BP is elevated from _________
A
- Hypotension
- hypovolemic
- anxiety
