Benzodiazepines Flashcards
1
Q
Goal of BZDs
A
Benzos allow GABA to work better
2
Q
GABA A receptors work?
A
Centrally Acting
3
Q
a1 receptor
A
Help with sleep
4
Q
a2 and a3 receptor
A
anxiety (aim)
5
Q
a5 receptor
A
memory
6
Q
b3 receptor
A
respiratory
7
Q
GABA B
A
muscle relaxant
8
Q
Benzos MOA
A
- BZDs bind to the GABAa alpha1,2,3Beta2Gamma2 area so GABA will bind more potently to the receptor
- Increased GABA effect; BZDs don’t stimulate receptor or increase GABA concentration
9
Q
Drugs
A
Triazolam Clonazepam Alprazoplam Lorazepam Diazepam Oxazepam Chlorodiazepoxide Zolpidem* Escoplicone* Zaleplon*
10
Q
ADEs
A
Sedation Cognitive impairment Ataxia/ Incoordination Respiratory Depression Anterograde Amnesia Paradoxical Agitation
11
Q
DDIs
A
NO BENZOS and OPIOIDS
