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Renal Exam 2 > Benign Prostatic Hyperplasia > Flashcards

Benign Prostatic Hyperplasia Flashcards

1
Q

Epithelial tissue =

A

Produces prostatic secretion

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2
Q

Stromal tissue

A

SM contraction if alpha-adrenergic receptor stimulated

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3
Q

Capsule tissue

A

Fibrous, connective tissue that also contracts with alpha-adrenergic receptor stimulated

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4
Q

Adrenergic receptor location?

A

Mainly is prostate but a few are within the bladder

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5
Q

Static factors =

A

growing prostate around the urethra

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6
Q

Dynamic factors =

A

alpha-adrenergic receptor stimulation in the urethra and bladder neck

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7
Q

Detrusor factor

A

Irritability of the detrusor secondary to long-standing BOO

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8
Q

Symptoms of Benign Prostatic Hyperplasia

A

Obstructive: diminished stream, urinary hesitancy, incontinence
Irritative: urinary frequency and urgency, nocturia

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9
Q

Goals of therapy

A

Relieve symptoms
Prevent complications
Reduce need for surgical intervention

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10
Q

Mild

A

Asymptomatic

Urinary flow rate 25-50 mL

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11
Q

Moderate

A

Mild + Obstructive voiding symptoms and irritative voiding symptoms

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12
Q

Severe

A

Moderate + Complication of BPH

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13
Q

Mild treatment

A

Watchful waiting

Smoking cessation, exercise

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14
Q

Alpha-adrenergic antagonists

A

***Do NOT reduce prostate size

Relax sphincter and SM

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15
Q

Alpha-adrenergic antagonists Drugs

A 
Prazosin
Terazosin
Doxasodin
Alfuzosin
Tamsulosin and silodosin (3rd gen)
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16
Q

Hytrin =

A

terazosin

17
Q

Cardura =

A

Doxazosin

18
Q

Flomax =

A

Tamsulosin

19
Q

Alpha-adrenergic antagonists 2nd Gen AE

A

***orthostatic hypoTN
Cardura IR 1 mg PO HS
Hytrin 1 mg PO HS

20
Q

Alpha-adrenergic antagonists 3rd Gen AE

A

Used in pts that can’t handle hypotension

Tamsulosin (Flomax) 0.4 mg PO QD

21
Q

5 Alpha-reductase Inhibitors

A

***Reduce prostate size
Decrease DHT
2nd line in sexually active males

22
Q

5 Alpha-reductase Inhibitors AE

A

Sexual dysfunction, gynecomastia, decreased libido

***Pregnancy Cat X

23
Q

5 Alpha-reductase Inhibitors + Women

A

Should nto ahndle or come in contact with semen of men takin these if you are pregnant or seeking to become pregnant

24
Q

5 Alpha-reductase Inhibitors + Women

A

Should not handle or come in contact with semen of men takin these if you are pregnant or seeking to become pregnant

25
Q

5 Alpha-reductase Inhibitors Drugs/dosing

A

Dutasteride (Avodart) 0.5 mg PO daily

Finasteride (Proscar) 5 mg PO daily

26
Q

General treatment for ALL pts =

A

Alpha adrenergic antagonists

27
Q

Pts with enlarged prostate treatment =

A

5 Alpha-reductase Inhibitors + alpha adrenergic antagonist

Renal Exam 2 (10 decks)

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